Canine atopic dermatitis attenuated by mesenchymal stem cells.
| Autor: | de Oliveira Ramos F; Department of Dermatology, Pet Especialidades Centro Veterinário, Brasilia, Brazil., Malard PF; Biocell Laboratory Celular Therapy, Brasilia, Brazil., Brunel HDSS; Biocell Laboratory Celular Therapy, Brasilia, Brazil., Paludo GR; Faculty of Agronomy and Veterinary Medicine, University of Brasilia, Brasilia, Brazil., de Castro MB; Faculty of Agronomy and Veterinary Medicine, University of Brasilia, Brasilia, Brazil., da Silva PHS; Faculty of Agronomy and Veterinary Medicine, University of Brasilia, Brasilia, Brazil., da Cunha Barreto-Vianna AR; Department of Bioscience, Federal University of Parana - Palotina Sector, Palotina, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of advanced veterinary and animal research [J Adv Vet Anim Res] 2020 Sep 01; Vol. 7 (3), pp. 554-565. Date of Electronic Publication: 2020 Sep 01 (Print Publication: 2020). |
| DOI: | 10.5455/javar.2020.g453 |
| Abstrakt: | Objective: To evaluate the use of mesenchymal stem cells (MSCs) in the attenuation of canine atopic dermatitis (AD). Materials and Methods: Sixteen dogs were selected and divided into three groups, mild, moderate, and severe, according to the Canine Atopic Dermatitis Extent and Severity Index (CADESI-4). They were evaluated for 82 days. The protocol recommended in this experiment was to inject 2 × 10 6 /kg bodyweight of MSC's in all groups by the intravenous route with intervals of applications of 21 days. The degree of pruritus was evaluated by examining the visual analog scale, the CADESI-4, the histopathology of the skin, hematological and biochemical parameters, the pyogenic effect of MSCs, and the thickness of the epidermis. Results: There was a significant difference in the reduction of epidermal thickness in the moderate and severe groups. Hematological, biochemical, and body temperature parameters remained within normal limits for the species with no side effects. Conclusion: MSCs attenuated the clinical signs of AD. Competing Interests: The authors declare that there is no conflict of interest. (Copyright: © Journal of Advanced Veterinary and Animal Research.) |
| Databáze: | MEDLINE |
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