Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects.

Autor: Yao Y; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA., Kauffmann F; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA.; Department of Oral and Craniomaxillofacial Surgery, Center for Dental Medicine, University Medical Center Freiburg, 79110, Freiburg, Germany., Maekawa S; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA.; Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan., Sarment LV; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA., Sugai JV; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA., Schmiedeler CA; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA., Doherty EJ; Wyss Institute for Biologically Inspired Engineering at Harvard University, Cambridge, MA, 02115, USA., Holdsworth G; UCB Pharma, Slough, SL1 3WE, UK., Kostenuik PJ; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA., Giannobile WV; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109, USA. William_Giannobile@hsdm.harvard.edu.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109-2800, USA. William_Giannobile@hsdm.harvard.edu.; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48019, USA. William_Giannobile@hsdm.harvard.edu.; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, 02115, USA. William_Giannobile@hsdm.harvard.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Oct 01; Vol. 10 (1), pp. 16217. Date of Electronic Publication: 2020 Oct 01.
DOI: 10.1038/s41598-020-73026-y
Abstrakt: Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or following tumor resection. Common reconstructive therapy can include the use of bone grafts with limited predictability and efficacy. Romosozumab, approved by the FDA in 2019, is a humanized sclerostin-neutralizing antibody (Scl-Ab) indicated in postmenopausal women with osteoporosis at high risk for fracture. Preclinical models show that Scl-Ab administration preserves bone volume during periodontal disease, repairs bone defects surrounding dental implants, and reverses alveolar bone loss following extraction socket remodeling. To date, there are no studies evaluating Scl-Ab to repair osseous defects around teeth or to identify the efficacy of locally-delivered Scl-Ab for targeted drug delivery. In this investigation, the use of systemically-delivered versus low dose locally-delivered Scl-Ab via poly(lactic-co-glycolic) acid (PLGA) microspheres (MSs) was compared at experimentally-created alveolar bone defects in rats. Systemic Scl-Ab administration improved bone regeneration and tended to increase cementogenesis measured by histology and microcomputed tomography, while Scl-Ab delivered by MSs did not result in enhancements in bone or cemental repair compared to MSs alone or control. In conclusion, systemic administration of Scl-Ab promotes bone and cemental regeneration while local, low dose delivery did not heal periodontal osseous defects in this study.
Databáze: MEDLINE
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