IL-5 mediates monocyte phenotype and pain outcomes in fibromyalgia.

Autor:	Merriwether EN; Inclusive and Translational Research in Pain Lab, Department of Physical Therapy, Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, United States.; Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Agalave NM; Neuroimmunology and Behavior Lab, School of Brain and Behavioral Science, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, United States., Dailey DL; Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States.; Department of Physical Therapy, Center for Health Sciences, St. Ambrose University, Davenport, IA, United States., Rakel BA; College of Nursing, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Kolker SJ; Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Lenert ME; Neuroimmunology and Behavior Lab, School of Brain and Behavioral Science, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, United States., Spagnola WH; Department of Applied Statistics, Social Science, and Humanities, NYU Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, United States., Lu Y; Department of Applied Statistics, Social Science, and Humanities, NYU Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, United States., Geasland KM; Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Allen LH; Departments of Medicine, Microbiology, Immunology, University of Iowa, Iowa City, IA, United States., Burton MD; Neuroimmunology and Behavior Lab, School of Brain and Behavioral Science, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, United States., Sluka KA; Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Jazyk:	angličtina
Zdroj:	Pain [Pain] 2021 May 01; Vol. 162 (5), pp. 1468-1482.
DOI:	10.1097/j.pain.0000000000002089
Abstrakt:	Abstract: Fibromyalgia (FM) is characterized by widespread chronic pain, fatigue, and somatic symptoms. The influence of phenotypic changes in monocytes on symptoms associated with FM is not fully understood. The primary aim of this study was to take a comprehensive whole-body to molecular approach in characterizing relationships between monocyte phenotype and FM symptoms in relevant clinical populations. Lipopolysaccharide-evoked and spontaneous secretion of IL-5 and other select cytokines from circulating monocytes was higher in women with FM compared to women without pain. In addition, greater secretion of IL-5 was significantly associated with pain and other clinically relevant psychological and somatic symptoms of FM. Furthermore, higher levels of pain and pain-related symptoms were associated with a lower percentage of intermediate monocytes (CD14++/CD16+) and a greater percentage of nonclassical monocytes (CD14+/CD16++) in women with FM. Based on findings from individuals with FM, we examined the role of IL-5, an atypical cytokine secreted from monocytes, in an animal model of widespread muscle pain. Results from the animal model show that IL-5 produces analgesia and polarizes monocytes toward an anti-inflammatory phenotype (CD206+). Taken together, our data suggest that monocyte phenotype and their cytokine profiles are associated with pain-related symptoms in individuals with FM. Furthermore, our data show that IL-5 has a potential role in analgesia in an animal model of FM. Thus, targeting anti-inflammatory cytokines such as IL-5 secreted by circulating leukocytes could serve as a promising intervention to control pain and other somatic symptoms associated with FM. (Copyright © 2020 International Association for the Study of Pain.)
Databáze:	MEDLINE
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