| Autor: |
Weimer P; Faculdade de Farmácia, Universidade do Vale do Rio dos Sinos (UNISINOS), São Leopoldo, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Spies LM; Faculdade de Farmácia, Universidade Feevale, Novo Hamburgo, Brazil., Haubert R; Faculdade de Farmácia, Universidade Feevale, Novo Hamburgo, Brazil., de Lima JAS; Departamento Administrativo, Universidade do Vale do Rio dos Sinos (UNISINOS), São Leopoldo, Brazil., Maluf RW; Faculdade de Farmácia, Universidade Feevale, Novo Hamburgo, Brazil., Rossi RC; Faculdade de Farmácia, Universidade do Vale do Rio dos Sinos (UNISINOS), São Leopoldo, Brazil.; Programa de Pós-Graduação em Nutrição e Alimentos, Universidade do Vale do Rio dos Sinos (UNISINOS), São Leopoldo, Brazil., Suyenaga ES; Faculdade de Farmácia, Universidade do Vale do Rio dos Sinos (UNISINOS), São Leopoldo, Brazil.; Faculdade de Farmácia, Universidade Feevale, Novo Hamburgo, Brazil. |
| Abstrakt: |
Brunfelsia uniflora (Pohl) D. Don roots have been widely used in folk medicine for treating inflammatory conditions. However, few studies have elucidated compounds that justify their traditional use. This study was conducted to characterize the phytochemical profile and evaluate the in vitro antioxidant capacity, and in vivo anti-inflammatory activity of extracts obtained from B. uniflora roots by comparing an herbal remedy (HR) with the crude hydroalcoholic extract (CHE). In the phytochemical analysis, scopoletin was identified as the marker compound. In quantitative analyses, CHE showed better results than HR. Furthermore, CHE had an effective anti-inflammatory activity. Animals treated with CHE (200 mg/kg) showed an 89.1% and a 73.8% reduction in edema volume after 1 hour of edema induction compared with those treated with negative control and positive control (indomethacin), respectively. These results show that B. uniflora root extracts have promising antioxidant and anti-inflammatory activities, thus corroborating their application in ethnomedicine. |
