| Autor: |
Bonnerup S; Department of Pathology, Sanford Health, Fargo, ND, USA., Gitau M; Department of Hematology and Oncology, Sanford Health, Fargo, ND, USA., Shafique K; Department of Pathology, Sanford Health, Fargo, ND, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Ear, nose, & throat journal [Ear Nose Throat J] 2022 Jul; Vol. 101 (6), pp. 386-391. Date of Electronic Publication: 2020 Sep 30. |
| DOI: |
10.1177/0145561320955125 |
| Abstrakt: |
Sinonasal lymphoepithelial carcinoma (SLEC) is an extremely rare malignancy. We present a case of SLEC in a 77-year-old man who presented with nasal congestion and persistent sinusitis. Imaging revealed a large right nasal mass involving right paranasal sinuses along with bulky bilateral cervical lymphadenopathy. In addition, there was a fluorodeoxyglucose avid L1 vertebral lesion. Biopsy of nasal mass and cervical lymph nodes showed syncytial growth of tumor cells in a lymphoplasmacytic background. Immunohistochemical stains showed positivity for pankeratin, CK5/6, epithelial membrane antigen, p40 (focal), and p63 (focal). An Epstein-Barr virus-encoded RNA by in situ hybridization was strong and diffusely positive. Based on these pathologic findings and considering the location of tumor, diagnosis of SLEC was rendered. L1 vertebral body lesion was clinical and radiologically considered to be a metastasis. Correlation with radiology to determine the exact location of tumor is extremely important for correct diagnosis due to its histopathologic similarities with relatively more common undifferentiated type of nasopharyngeal carcinoma. No standard treatment protocol has been established for this tumor yet. To our knowledge, this is first ever report of SLEC presented with clinical stage IV disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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