Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study for Alcohol Use Disorder.

Autor: Haass-Koffler CL; From the Department of Psychiatry and Human Behavior (CLH-K, RMS, GAK), Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.; Department of Behavioral and Social Sciences (CLH-K, VML, LL), Center for Alcohol and Addiction Studies, School of Public Health, Brown University, Providence, Rhode Island.; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section (CLH-K, DP, MRL, LL), National Institute on Drug Abuse Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, Maryland., Piacentino D; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section (CLH-K, DP, MRL, LL), National Institute on Drug Abuse Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, Maryland.; Center on Compulsive Behaviors (DP, LL), National Institutes of Health, Bethesda, Maryland., Li X; Biostatistics and Clinical Epidemiology Services (XL), National Institutes of Health, Bethesda, Maryland., Long VM; Department of Behavioral and Social Sciences (CLH-K, VML, LL), Center for Alcohol and Addiction Studies, School of Public Health, Brown University, Providence, Rhode Island., Lee MR; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section (CLH-K, DP, MRL, LL), National Institute on Drug Abuse Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, Maryland., Swift RM; From the Department of Psychiatry and Human Behavior (CLH-K, RMS, GAK), Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.; Veterans Affairs Medical Center (RMS), Providence, Rhode Island., Kenna GA; From the Department of Psychiatry and Human Behavior (CLH-K, RMS, GAK), Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island., Leggio L; Department of Behavioral and Social Sciences (CLH-K, VML, LL), Center for Alcohol and Addiction Studies, School of Public Health, Brown University, Providence, Rhode Island.; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section (CLH-K, DP, MRL, LL), National Institute on Drug Abuse Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, Maryland.; Center on Compulsive Behaviors (DP, LL), National Institutes of Health, Bethesda, Maryland.; Medication Development Program (LL), National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland.; Division of Addiction Medicine (LL), Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.; Department of Neuroscience (LL), Georgetown University Medical Center, Washington, District of Columbia.
Jazyk: angličtina
Zdroj: Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2020 Oct; Vol. 44 (10), pp. 2097-2108. Date of Electronic Publication: 2020 Sep 30.
DOI: 10.1111/acer.14428
Abstrakt: Background: One of the challenges in early-stage clinical research aimed at developing novel treatments for alcohol use disorder (AUD) is that the enrolled participants are heavy drinkers, but do not seek treatment for AUD.
Aims: To compare nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies conducted at Brown University (N = 240; 65.4% male) to treatment seekers with AD from the multisite COMBINE study (N = 1,383; 69.1% male) across sociodemographic and alcohol-related clinical variables and to evaluate whether the variables that significantly differentiate the 2 samples predict the 3 main COMBINE clinical outcomes: time to relapse, percent days abstinent (PDA), and good clinical outcome.
Methods: Sample characteristics were assessed by parametric and nonparametric testing. Three regression models measured the association between the differing variables and the 3 main COMBINE clinical outcomes.
Results: The nontreatment seekers, compared to the treatment seekers, were more ethnically diverse, less educated, single, and working part-time or unemployed (p's < 0.05); they met fewer DSM-IV AD criteria and had significantly lower scores on alcohol-related scales (p's < 0.05); they were less likely to have a father with alcohol problems (p < 0.0001) and had a significantly earlier age of onset and longer duration of AD (p's < 0.05); they also had significantly more total drinks, drinks per drinking day, heavy drinking days (HDD), and lower PDA in the 30 days prior to baseline (p's < 0.0001 to <0.05). Having more HDD in the 30 days prior to baseline predicted all of the 3 COMBINE clinical outcomes. All the other characteristics mentioned above that differed significantly between the 2 groups predicted at least 1 of the 3 COMBINE clinical outcomes, except for level of education, age of onset, and duration of AD.
Conclusions: The observed differences between groups should be considered in efforts across participant recruitment at different stages of the development of new treatments for AUD.
(© 2020 by the Research Society on Alcoholism. This article has been contributed to by US Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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