Single cell sequencing unraveling genetic basis of severe COVID19 in obesity.

Autor: AbdelMassih AF; Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, Egypt.; Pediatric Cardio-Oncology Department, Children Cancer Hospital of Egypt, 57357, Egypt., Fouda R; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt.; University of Irvine California, USA., Kamel A; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Mishriky F; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Ismail HA; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., El Qadi L; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Malak L; Pediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, Egypt., Mohamed M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Arsanyous M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Hazem M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., El-Husseiny M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Ashraf M; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Hafez N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., AlShehry N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., El-Husseiny N; Faculty of Dentistry, Cairo University, Egypt.; Pixagon Graphic Design Agency, Cairo, Egypt., AbdelRaouf N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Shebl N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Hafez N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Youssef N; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Afdal P; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Hozaien R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Menshawey R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Saeed R; Student and Internship Research Program (Research Accessibility Team), Faculty of Medicine, Cairo University, Egypt., Yasser R; Department of Pharmaceutical and Pharmacological Sciences, Faculty of Medicine, Padova University, Padova, Italy., Hesham S; Pediatrics' Department, 6th October University, Cairo, Egypt., Zakarriah W; Residency Training Program, Faculty of Medicine, Cairo University, Egypt., Khattab S; Student and Internship Research Program (Research Accessibility Team), Faculty of Pharmacy, Cairo University, Egypt., Elammary Y; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt., Ye J; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Jazyk: angličtina
Zdroj: Obesity medicine [Obes Med] 2020 Dec; Vol. 20, pp. 100303. Date of Electronic Publication: 2020 Sep 24.
DOI: 10.1016/j.obmed.2020.100303
Abstrakt: COVID-19 has shown a substantial variation in the rate and severity by which it impacts different demographic groups. Specifically, it has shown a predilection towards obese patients as well as well as other vulnerable groups including predilection of males over females, old age over young age and black races over Caucasian ones. Single cell sequencing studies have highlighted the role of cell polarity and the co-expression of proteases, such as Furin, along with ACE2 in the genesis of coronavirus disease rather than exclusively link tissue involvement with ACE2 levels thought previously. It has also forged a connection between the genetic and immune cellular mechanisms underlying COVID infection and the inflammatory state of obese patients, offering a more accurate explanation as to why obese patients are at increased risk of poor COVID outcomes. These commonalities encompass macrophage phenotype switching, genetic expression switching, and overexpression of the pro-inflammatory cytokines, depletion of the regulatory cytokines, in situ T cell proliferation, and T cell exhaustion. These findings demonstrate the necessity of single cell sequencing as a rapid means to identify and treat those who are most likely to need hospital admission and intensive care, in the hopes of precision medicine. Furthermore, this study underlines the use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one.
Competing Interests: Authors declare that there is no conflict of interest.
(© 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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