Enhancing degradability, bioactivity, and osteocompatibility of poly (propylene fumarate) bone filler by incorporation of Mg-Ca-P nanoparticles.

Autor: Karfarma M; School of Metallurgical and Materials Engineering, Iran University of Science and Technology, Narmak, Tehran 16844, Iran. Electronic address: m.karfarma@gmail.com., Esnaashary MH; School of Metallurgical and Materials Engineering, Iran University of Science and Technology, Narmak, Tehran 16844, Iran., Rezaie HR; School of Metallurgical and Materials Engineering, Iran University of Science and Technology, Narmak, Tehran 16844, Iran., Javadpour J; School of Metallurgical and Materials Engineering, Iran University of Science and Technology, Narmak, Tehran 16844, Iran., Naimi-Jamal MR; Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, Narmak, Tehran 16844, Iran.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Sep; Vol. 114, pp. 111038. Date of Electronic Publication: 2020 May 01.
DOI: 10.1016/j.msec.2020.111038
Abstrakt: As an alternative for polymethyl methacrylate, poly(propylene fumarate) (PPF) has been considered as injectable and biodegradable bone cement; however, its mechanical and biological properties need more attention. Hence, the current study aimed to develop the properties by compositing PPF with magnesium calcium phosphate (MCP) nano-powders. In this regard, the pure PPF was compared with PPF/MCP by evaluating their composition, mechanical properties, hydrophilicity, and biodegradability. Furthermore, their bioactivity in the simulated body fluid (SBF) and, via applying MG-63 cells, their cell interaction, including proliferation, adhesion, differentiation, and mineralization, were assessed. The addition of MCP improved compressive strength and elastic modulus of PPF, e.g., 10 wt% MCP increased them to 32.7 and 403 MPa, respectively. Also, hydrophilicity and biodegradation of PPF were enhanced in the presence of MCP; so that the highest hydrophilicity, 42% higher than PPF, was achieved at the presence of 20 wt% MCP. In this condition, after 21-day immersion in SBF, the surface of the sample was covered with a dense and continuous layer of hydroxyapatite. The composite proliferation, adhesion, differentiation, and mineralization of MG-63 cells improved in comparison to the pure PPF. Hence, controllable strength and biodegradation of the composite, along with its proved bioactivity and osteoconductivity, make PPF/MCP as a candidate for bone therapeutic application.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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