Human seroepidemiology of Rickettsia and Orientia species in Chile - A cross-sectional study in five regions.

Autor: Weitzel T; Laboratorio Clínico, Clínica Alemana, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile; Instituto de Ciencias e Innovación en Medicina (ICIM) Facultad de Medicina Clínica Alemana Universidad del Desarrollo Santiago Chile. Electronic address: thomas.weitzel@gmail.com., Acosta-Jamett G; Instituto de Medicina Preventiva Veterinaria y Programa de Investigación Aplicada en Fauna Silvestre, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile. Electronic address: gerardo.acosta@uach.cl., Jiang J; Viral and Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD, USA. Electronic address: jjiang@hjfresearch.org., Martínez-Valdebenito C; Departamento de Enfermedades Infecciosas e Inmunología Pediátricas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: cmartinezv@med.puc.cl., Farris CM; Viral and Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD, USA. Electronic address: christina.m.farris3.civ@mail.mil., Richards AL; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences. Bethesda, MD, USA. Electronic address: allen.richards@comcast.net., Abarca K; Departamento de Enfermedades Infecciosas e Inmunología Pediátricas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address: katia@med.puc.cl.
Jazyk: angličtina
Zdroj: Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2020 Nov; Vol. 11 (6), pp. 101503. Date of Electronic Publication: 2020 Jul 01.
DOI: 10.1016/j.ttbdis.2020.101503
Abstrakt: In recent years, the spectrum and epidemiology of human rickettsioses has become an emerging topic in Chile. This survey aimed to assess the seroprevalence of spotted fever group rickettsiae (SFGR), typhus group rickettsiae (TGR), and scrub typhus group orientiae (STGO) in northern, central, and southern Chile. We performed a cross-sectional study of healthy adults in rural and urban settings of five regions. Participants were chosen by double stratified random sampling in urban and by convenience in rural locations (n = 1302). Serum specimens were analyzed for group-specific IgG antibodies against SFGR, TGR, and STGO by enzyme-linked immunosorbent assays (ELISAs). Overall seroprevalences to SFGR, TGR, and STGO were 5.3 %, 1.2 %, and 0.4 %, respectively. Prevalences showed geographical differences. Statistical analyses revealed an association of older age with seropositivity to SFGR and to TGR and of rural setting and male gender with seropositivity to SFGR. The study indicates that SFGR, TGR, and STGO are endemic in Chile. The very low STGO seroprevalence might indicate an insufficient sensitivity of serological tests using Asian O. tsutsugamushi strains as ELISA antigens for the detection of antibodies against Chilean Orientia species.
(Copyright © 2020 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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