| Autor: |
Inizan C; Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia., O'Connor O; Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia., Worwor G; Surveillance, Emergency and Research Unit, Ministry of Health, Port Vila, Vanuatu., Cabemaiwai T; National Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, Fiji., Grignon JC; Laboratoire de Biologie Médicale, Hôpital de Sia, Mata'Utu 98600, Wallis et Futuna., Girault D; Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia., Minier M; Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia., Prot M; Institut Pasteur, Evolutionary Genomics of RNA Viruses, 75015 Paris, France., Ballan V; Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia., Pakoa GJ; Surveillance, Emergency and Research Unit, Ministry of Health, Port Vila, Vanuatu., Grangeon JP; New Caledonia Health Authorities (Direction des Affaires Sanitaires et Sociales-Nouvelle-Calédonie, DASS-NC), Noumea 98800, New Caledonia., Guyant P; WHO Country Liaison Office, Port Vila, Vanuatu., Lepers C; Pacific Community (SPC), Noumea 98800, New Caledonia., Faktaufon D; National Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, Fiji., Sahukhan A; National Public Health Laboratory, Fiji Centre For Communicable Disease Control, Suva, Fiji., Merilles OE Jr; Pacific Community (SPC), Noumea 98800, New Caledonia., Gourinat AC; Centre Hospitalier Territorial, Microbiology Laboratory, Dumbea-sur-Mer, Dumbea 98835, New Caledonia., Simon-Lorière E; Institut Pasteur, Evolutionary Genomics of RNA Viruses, 75015 Paris, France., Dupont-Rouzeyrol M; Institut Pasteur de Nouvelle-Calédonie, Institut Pasteur International Network, URE Dengue et Arboviroses, Noumea 98800, New Caledonia. |
| Abstrakt: |
Dengue virus (DENV) serotype-2 was detected in the South Pacific region in 2014 for the first time in 15 years. In 2016-2020, DENV-2 re-emerged in French Polynesia, Vanuatu, Wallis and Futuna, and New Caledonia, co-circulating with and later replacing DENV-1. In this context, epidemiological and molecular evolution data are paramount to decipher the diffusion route of this DENV-2 in the South Pacific region. In the current work, the E gene from 23 DENV-2 serum samples collected in Vanuatu, Fiji, Wallis and Futuna, and New Caledonia was sequenced. Both maximum likelihood and Bayesian phylogenetic analyses were performed. While all DENV-2 strains sequenced belong to the Cosmopolitan genotype, phylogenetic analysis suggests at least three different DENV-2 introductions in the South Pacific between 2017 and 2020. Strains retrieved in these Pacific Islands Countries and Territories (PICTs) in 2017-2020 are phylogenetically related, with strong phylogenetic links between strains retrieved from French PICTs. These phylogenetic data substantiate epidemiological data of the DENV-2 diffusion pattern between these countries. |
