Efficacy and safety of mirogabalin treatment in patients with diabetic peripheral neuropathic pain: A systematic review and meta-analysis of randomised controlled trials.

Autor:	Alyoubi RA; Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Alshareef AA; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Aldughaither SM; Department of Internal Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Aljaroudi AM; Department of Internal Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Alabdulwahed A; Department of Internal Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Alduraibi FM; Department of Internal Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Masoud AT; Faculty of Medicine, Fayoum University, Fayoum, Egypt., Abu-Zaid A; Department of Internal Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.; Department of Pharmacology, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Jazyk:	angličtina
Zdroj:	International journal of clinical practice [Int J Clin Pract] 2021 May; Vol. 75 (5), pp. e13744. Date of Electronic Publication: 2020 Oct 27.
DOI:	10.1111/ijcp.13744
Abstrakt:	Aim: We aimed to perform a systematic review and meta-analysis to examine the efficacy and safety of mirogabalin in patients with diabetic peripheral neuropathic pain (DPNP). Methods: We searched four databases from inception to 1st July 2020. We included all randomised controlled trials (RCTs) which assessed the effectiveness and safety of mirogabalin in patients with DPNP. We evaluated the quality of the included RCTs using the Cochrane risk of bias assessment tool. We pooled dichotomous outcomes as risk ratios and continuous outcomes as mean differences with 95% confidence intervals, both under the random- or fixed-effects model. Results: Three RCTs matched our inclusion criteria with a total of 1732 patients with DPNP: 1057, 534 and 141 patients received mirogabalin, placebo and pregabalin, respectively. The quality of included RCTs was marked as moderate-to-high. Mirogabalin treatment was significantly associated with a significant reduction in the average daily pain score (ADPS) compared with placebo over 7 weeks. Compared with pregabalin, mirogabalin was significantly associated with more decrease in ADPS only after 3, 4 and 5 weeks. The proportion of patients with ≥30% and ≥50% reduction in the ADPS was significantly higher in the mirogabalin vs placebo and pregabalin groups. Compared with placebo, mirogabalin was significantly associated with more adverse events of dizziness, increased weight, peripheral oedema and somnolence. The safety profile was comparable between mirogabalin and pregabalin. Conclusions: Our systematic review and meta-analysis revealed that in patients with DPNP, mirogabalin treatment was superior to placebo and pregabalin in decreasing the ADPS over time. Besides, mirogabalin was largely safe and associated with some adverse events that could be managed conservatively. (© 2020 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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