Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy.

Autor: Devillier R; Immunity and Cancer Team, Paoli-Calmettes Institute, Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.; Immunomonitoring platform, Paoli-Calmettes Institute, Marseille, France.; Hematology Department, Paoli-Calmettes Institute, Marseille, France., Chrétien AS; Immunity and Cancer Team, Paoli-Calmettes Institute, Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.; Immunomonitoring platform, Paoli-Calmettes Institute, Marseille, France., Pagliardini T; Immunity and Cancer Team, Paoli-Calmettes Institute, Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.; Immunomonitoring platform, Paoli-Calmettes Institute, Marseille, France.; Hematology Department, Paoli-Calmettes Institute, Marseille, France., Salem N; Immunity and Cancer Team, Paoli-Calmettes Institute, Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.; Immunomonitoring platform, Paoli-Calmettes Institute, Marseille, France., Blaise D; Immunity and Cancer Team, Paoli-Calmettes Institute, Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.; Immunomonitoring platform, Paoli-Calmettes Institute, Marseille, France.; Hematology Department, Paoli-Calmettes Institute, Marseille, France., Olive D; Immunity and Cancer Team, Paoli-Calmettes Institute, Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.; Immunomonitoring platform, Paoli-Calmettes Institute, Marseille, France.
Jazyk: angličtina
Zdroj: Journal of leukocyte biology [J Leukoc Biol] 2021 Jun; Vol. 109 (6), pp. 1071-1088. Date of Electronic Publication: 2020 Sep 29.
DOI: 10.1002/JLB.5MR0920-198RR
Abstrakt: NK cells are innate immune cells with inherent capabilities in both recognizing and killing cancer cells. NK cell phenotypes and functional alterations are being described with increasing precision among patients harboring various cancer types, emphasizing the critical role that NK cells play in antitumor immune responses. In addition, advances in understanding NK cell biology have improved our knowledge of such alterations, thereby expanding the potential exploitation of NK cells' anticancer capabilities. In this review, we present an overview of (1) the various types of NK cell alterations that may contribute to immune evasion in cancer patients and (2) the various strategies to improve NK cell-based anticancer immunotherapies, including pharmacologic modulation and/or genetic modification.
(©2020 Society for Leukocyte Biology.)
Databáze: MEDLINE
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