Acute kidney injury among salicylate intoxication hospitalisations in the United States.

Autor:	Thongprayoon C; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Petnak T; Division of Pulmonary and Pulmonary Critical Care Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Kaewput W; Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand., Qureshi F; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Mao MA; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA., Pivovarova AI; Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Boonpheng B; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Bathini T; Department of Internal Medicine, University of Arizona, Tucson, AZ, USA., Vallabhajosyula S; Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Medaura J; Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Cheungpasitporn W; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.; Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Jazyk:	angličtina
Zdroj:	International journal of clinical practice [Int J Clin Pract] 2021 Mar; Vol. 75 (3), pp. e13745. Date of Electronic Publication: 2020 Oct 27.
DOI:	10.1111/ijcp.13745
Abstrakt:	Background: This study aimed to evaluate the risk factors and the association of acute kidney injury (AKI) with outcomes, and resource utilisation in patients hospitalised because of salicylate intoxication in the United States. Methods: Hospitalised patients with a primary diagnosis of salicylate intoxication from 2003 to 2014 were identified in the National Inpatient Sample (NIS) database. End-stage kidney disease patients were excluded. The occurrence of AKI was identified using hospital diagnosis code. Clinical characteristics, in-hospital treatment, outcomes and resource utilisation were compared between patients with and without AKI. Results: A total of 13 787 eligible hospital admissions were included in the analysis. AKI occurred in 1279 (9.3%) admissions. Older age, male sex, more recent year of hospitalisation, anaemia, hypertension, congestive heart failure, chronic kidney disease, volume depletion, sepsis and ventricular arrhythmia/cardiac arrest were significantly associated with increased risk of AKI, whereas Hispanic race was associated with decreased risk. AKI was significantly associated with increased risk of organ failure, and in-hospital mortality. In addition, the need for ventilation support, blood component transfusion, renal replacement therapy, length of hospital stay and hospitalisation cost were higher in AKI patients. Conclusion: Approximately one tenth of salicylate intoxication patients developed AKI during hospitalisation. AKI was associated with higher morbidity, mortality and resource utilisations. (© 2020 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu