Correlation between human papillomavirus infection and histopathological diagnosis of women in Northeast Brazil.

Autor: Miranda PJC; Department of Pathology, Center for Health Sciences, Federal University of Pernambuco, Recife, Brazil., Chagas BS; Department of Genetics, Center for Biosciences, Federal University of Pernambuco, Recife, Brazil., Coêlho MRCD; Department of Physiology and Pharmacology, Center for Biosciences, Federal University of Pernambuco, Recife, Brazil.; Virology Sector, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Brazil., Silva Neto JDC; Department of Histology, Center for Biosciences, Federal University of Pernambuco, Recife, Brazil.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2020 Dec; Vol. 92 (12), pp. 3799-3806. Date of Electronic Publication: 2020 Sep 28.
DOI: 10.1002/jmv.26101
Abstrakt: Cervical carcinoma is the fourth leading cause of death among women worldwide. Epidemiological studies claim that human papillomavirus (HPV) infection is a necessary condition for cervical cancer development. Knowledge of the geographic distribution of HPV is important in guiding the introduction of prophylactic vaccines. This study analyzed the prevalence of HPV infection in cervical samples obtained from women with abnormal cervical histopathological diagnosis in Northeast Brazil. The study included an analysis of 211 women whose diagnosis was confirmed for cervical intraepithelial neoplasia type 1 (CIN-1), cervical intraepithelial neoplasia type 2 (CIN-2), cervical intraepithelial neoplasia type 3 (CIN-3), and cancer. The identification of the HPV genotypes was based on the polymerase chain reaction-restriction fragment length polymorphism technique. A total of 42.7% of the samples showed a single HPV infection, while 57.3% showed multiple infections. The most common genotypes detected were HPV-16, HPV-18, and HPV-31. HPV-16, HPV-31, HPV-35, and HPV-18 were the most common types in CIN-1 with a single infection. HPV-16 and HPV-18 were the most often found in CIN-2 with a single infection. HPV-16, HPV-18, and HPV-31 were the most detected in CIN-3 with a single infection. HPV-16 and HPV-31 were the most frequent in cancer with a single infection. Multiple infection with HPV-16 shows a 2.7 times greater risk of CIN-3 (P = .04). Multiple infections for HPV with HPV-16 and excluding the HPV18/31 types, were associated with CIN-3 (P = .01). The results allowed the detection and genotyping of HPV types circulating in the population studied. These findings must be taken into account when devising vaccination strategies against HPV.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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