Preoperative Evaluation of Myxofibrosarcoma: Prognostic Value and Reproducibility of Different Features on MRI.

Autor:	MÜhlhofer H; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Gersing A; Department of Radiology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Pfeiffer D; Department of Radiology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., WÖrtler K; Department of Radiology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Lenze U; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Lenze F; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Lallinger V; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Haller B; Institute of Medical Informatics, Statistics and Epidemiology, Technical University of Munich, Munich, Germany., Burgkart R; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., VON Eisenhart-Rothe R; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Knebel C; Department of Orthopaedics and Sports Orthopaedics, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany carolin.knebel@mri.tum.de.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2020 Oct; Vol. 40 (10), pp. 5793-5800.
DOI:	10.21873/anticanres.14596
Abstrakt:	Background/aim: Myxofibrosarcoma (MFS) is characterized by an infiltrative growth pattern. This study aimed to determine the correlation between overall survival (OS) and morphological features of MFS as well as examine the reproducibility of these findings on preoperative magnetic resonance imaging (MRI). Patients and Methods: Fifty-eight MFS patients underwent preoperative MR imaging with the following features analysed: i) tumour size, ii) localization, iii) margins, iv) morphology, v) signal characteristics, vi) contrast enhancement, vii) presence and extent of perilesional oedema, and viii) presence of the tail sign. Results: Only circumscribed perilesional oedema was associated with a significantly better survival compared to diffuse oedema (p=0.010), which was found in the majority of cases. The tail sign was found in less than 50% of the cases. Cohen's kappa coefficients confirmed a relatively high interrater variability. Conclusion: Perilesional diffuse oedema on MR imaging of MFS is significantly correlated with a poor overall survival. The interrater variability in interpretation of MR examinations varies from slight to substantial agreement. Preoperative MR imaging with detailed planning of the resection seem to be a logical approach to achieve negative resection margins and recurrence-free survival. (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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