Spontaneus involution of meningioma. Case report and literature review.

Autor: Ortega Martínez M; Servicio de Neurocirugía, Complejo Hospitalario Universitario de Cáceres, Cáceres, España. Electronic address: marta.ort@hotmail.com., Gilete Tejero I; Servicio de Neurocirugía, Complejo Hospitalario Universitario de Cáceres, Cáceres, España., Miranda Zambrano D; Servicio de Neurocirugía, Complejo Hospitalario Universitario de Cáceres, Cáceres, España., Gestoso Ríos I; Servicio de Neurocirugía, Complejo Hospitalario Universitario de Cáceres, Cáceres, España., Rico Cotelo M; Servicio de Neurocirugía, Complejo Hospitalario Universitario de Cáceres, Cáceres, España., Royano Sánchez M; Servicio de Neurocirugía, Complejo Hospitalario Universitario de Cáceres, Cáceres, España.
Jazyk: English; Spanish; Castilian
Zdroj: Neurocirugia (English Edition) [Neurocirugia (Astur : Engl Ed)] 2020 Sep 25. Date of Electronic Publication: 2020 Sep 25.
DOI: 10.1016/j.neucir.2020.06.002
Abstrakt: Meningiomas are tumors of the cerebral meninges, with slow growth and usually benign, whose treatment is essentially surgery. They have progesterone receptors, and to a lesser extent estrogen, which sometimes causes them to have growth or involution linked to hormonal treatment. Its spontaneous involution is extremely rare. We present the case of a male with a meningioma of the sphenoid planum. He had a history of diabetes mellitus, myasthenia gravis and prostate cancer. He was in treatment with analogs of GnRH (leuprorelin), antiandrogen (bicalutamide), β3 agonists and α1 blockers. 15 months after the hormonal blockade, a reduction of the tumor of approximately 90% of its volume was detected. Previous reports show that treatment with gonadotropin analogues produces growth in some meningiomas. Other reports of spontaneous involution affect diabetic patients and patients in treatment with α1 blockers. Literature focus on meningiomas with spontaneous involution is reviewed.
(Copyright © 2020 Sociedad Española de Neurocirugía. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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