Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia.

Autor: Christiansen L; University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis and Miami VA Medical Center, Miami, FL, 33136, United States of America; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark., Chen B; University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis and Miami VA Medical Center, Miami, FL, 33136, United States of America; Shirley Ryan AbilityLab, Northwestern University, Chicago, IL 60611, United States of America., Lei Y; University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis and Miami VA Medical Center, Miami, FL, 33136, United States of America., Urbin MA; University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis and Miami VA Medical Center, Miami, FL, 33136, United States of America., Richardson MSA; Edward Jr. Hines VA Hospital, Chicago, IL 60141, United States of America., Oudega M; University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis and Miami VA Medical Center, Miami, FL, 33136, United States of America; Shirley Ryan AbilityLab, Northwestern University, Chicago, IL 60611, United States of America; Edward Jr. Hines VA Hospital, Chicago, IL 60141, United States of America; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Northwestern University, Chicago, IL 60611, United States of America; Affiliated Cancer Hospital & Institute, Guangzhou Medical University, Guangzhou, Guangdong 510095, PR China., Sandhu M; Shirley Ryan AbilityLab, Northwestern University, Chicago, IL 60611, United States of America., Rymer WZ; Shirley Ryan AbilityLab, Northwestern University, Chicago, IL 60611, United States of America., Trumbower RD; Spaulding Rehabilitation Hospital, Cambridge Street, Cambridge, MA 02138, United States of America; Harvard Medical School, Department of Physical Medicine & Rehabilitation, Boston, MA 02115, United States of America., Mitchell GS; Center for Respiratory Research and Rehabilitation, Department of Physical Therapy and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, United States of America., Perez MA; University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis and Miami VA Medical Center, Miami, FL, 33136, United States of America; Shirley Ryan AbilityLab, Northwestern University, Chicago, IL 60611, United States of America; Edward Jr. Hines VA Hospital, Chicago, IL 60141, United States of America; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Northwestern University, Chicago, IL 60611, United States of America. Electronic address: mperez04@SRALab.org.
Jazyk: angličtina
Zdroj: Experimental neurology [Exp Neurol] 2021 Jan; Vol. 335, pp. 113483. Date of Electronic Publication: 2020 Sep 25.
DOI: 10.1016/j.expneurol.2020.113483
Abstrakt: Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined whether PCMS-induced plasticity could be potentiated by acute intermittent hypoxia (AIH), a treatment also known to induce spinal synaptic plasticity in humans with chronic incomplete cervical SCI. During PCMS, we used 180 pairs of stimuli where corticospinal volleys evoked by transcranial magnetic stimulation over the hand representation of the primary motor cortex were timed to arrive at corticospinal-motoneuronal synapses of the first dorsal interosseous (FDI) muscle ~1-2 ms before the arrival of antidromic potentials elicited in motoneurons by electrical stimulation of the ulnar nerve. During AIH, participants were exposed to brief alternating episodes of hypoxic inspired gas (1 min episodes of 9% O 2 ) and room air (1 min episodes of 20.9% O 2 ). We examined corticospinal function by measuring motor evoked potentials (MEPs) elicited by cortical and subcortical stimulation of corticospinal axons and voluntary motor output in the FDI muscle before and after 30 min of PCMS combined with AIH (PCMS+AIH) or sham AIH (PCMS+sham-AIH). The amplitude of MEPs evoked by magnetic and electrical stimulation increased after both protocols, but most after PCMS+AIH, consistent with the hypothesis that their combined effects arise from spinal plasticity. Both protocols increased electromyographic activity in the FDI muscle to a similar extent. Thus, PCMS effects on spinal synapses of hand motoneurons can be potentiated by AIH. The possibility of different thresholds for physiological vs behavioral gains needs to be considered during combinatorial treatments.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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