Characteristics of Patients With Antiphospholipid Antibody Positivity in the APS ACTION International Clinical Database and Repository.

Autor: Sevim E; Hospital for Special Surgery, New York, New York, and Montefiore Medical Center, Bronx, New York., Zisa D; Hospital for Special Surgery and Weill Cornell Medicine, New York, New York., Andrade D; University of Sao Paulo, Sao Paulo, Brazil., Sciascia S; University of Turin, Turin, Italy., Pengo V; University Hospital Padova, Padova, Italy., Tektonidou MG; National and Kapodistrian University of Athens, Athens, Greece., Ugarte A; Hospital Universitario Cruces, Barakaldo, País Vasco, Spain., Gerosa M; University of Milan, Milan, Italy., Belmont HM; New York University Langone Medical Center, New York, New York., Zamorano MAA; Maimonides Institute for Biomedical Research of Cordoba, Cordoba, Spain., Fortin PR; CHU de Québec and Université Laval, Quebec City, Canada., Ji L; Peking University First Hospital, Beijing, China., Efthymiou M; University College London, London, UK., Cohen H; University College London, London, UK., Branch DW; University of Utah and Intermountain Healthcare, Salt Lake City, Utah., de Jesus GR; Rio de Janeiro State University, Rio de Janeiro, Brazil., Andreoli L; University of Brescia, Brescia, Italy., Petri M; Johns Hopkins University School of Medicine, Baltimore, Maryland., Rodriguez E; Hospital Universitario 12 de Octubre, Madrid, Spain., Cervera R; Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain., Knight JS; University of Michigan, Ann Arbor., Atsumi T; Hokkaido University Hospital, Sapporo, Japan., Willis R; University of Texas Medical Branch, Galveston., Roubey R; University of North Carolina, Chapel Hill., Bertolaccini ML; St Thomas' Hospital, London, UK., Erkan D; Hospital for Special Surgery and Weill Cornell Medicine, New York, New York., Barbhaiya M; Hospital for Special Surgery and Weill Cornell Medicine, New York, New York.
Jazyk: angličtina
Zdroj: Arthritis care & research [Arthritis Care Res (Hoboken)] 2022 Feb; Vol. 74 (2), pp. 324-335.
DOI: 10.1002/acr.24468
Abstrakt: Objective: To describe the baseline characteristics of patients with positivity for antiphospholipid antibodies (aPLs) who were enrolled in an international registry, the Antiphospholipid Syndrome (APS) Alliance for Clinical Trials and International Networking (APS ACTION) clinical database and repository, overall and by clinical and laboratory subtypes.
Methods: The APS ACTION registry includes adults who persistently had positivity for aPLs. We evaluated baseline sociodemographic and aPL-related (APS classification criteria and "non-criteria") characteristics of patients overall and in subgroups (aPL-positive without APS, APS overall, thrombotic APS only, obstetric APS only, and both thrombotic APS/obstetric APS). We assessed baseline characteristics of patients tested for the presence of three aPLs (lupus anticoagulant [LAC] test, anticardiolipin antibody [aCL], and anti-β 2 -glycoprotein I [anti-β 2 GPI]) antibodies by aPL profiles (LAC only, single, double, and triple aPL positivity).
Results: The 804 aPL-positive patients assessed in the present study had a mean age of 45 ± 13 years, were 74% female, and 68% White; additionally, 36% had other systemic autoimmune diseases. Of these 804 aPL-positive patients, 80% were classified as having APS (with 55% having thrombotic APS, 9% obstetric APS, and 15% thrombotic APS/obstetric APS). In the overall cohort, 71% had vascular thrombosis, 50% with a history of pregnancy had obstetric morbidity, and 56% had experienced at least one non-criteria manifestation. Among those with three aPLs tested (n = 660), 42% were triple aPL-positive. While single-, double-, and triple aPL-positive subgroups had similar frequencies of vascular, obstetric, and non-criteria events, these events were lowest in the single aPL subgroup, which consisted of aCLs or anti-β 2 GPI only.
Conclusion: Our study demonstrates the heterogeneity of aPL-related clinical manifestations and laboratory profiles in a multicenter international cohort. Within single aPL positivity, LAC may be a major contributor to clinical events. Future prospective analyses, using standardized core laboratory aPL tests, will help clarify aPL risk profiles and improve risk stratification.
(© 2020, American College of Rheumatology.)
Databáze: MEDLINE
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