Primordial odontogenic tumor: report of 2 new cases.

Autor: Delgado-Azañero WA; Servicio de Patología y Medicina Oral y Maxilofacial, Facultad de Estomatología, Universidad Peruana Cayetano Heredia, Lima, Peru., de Almeida OP; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil., Pereira AAC; Department of Pathology and Parasitology, Federal University of Alfenas, UNIFAL-MG, Alfenas, Brazil., de Oliveira CE; Department of Pathology and Parasitology, Federal University of Alfenas, UNIFAL-MG, Alfenas, Brazil., Dias MA; Department of Surgery, School of Dentistry, National Higher Education and Post-graduation Institute Padre Gervasio, INAPÓS, Pouso Alegre, Brazil., Florez-Valderrama G; Cirujano Maxilofacial, Hospital III Juliaca ESSALUD, Perú., de Lima Morais TM; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil., Mariz BALA; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil., Mosqueda-Taylor A; Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xochimilco, Mexico. Electronic address: mosqueda@correo.xoc.uam.mx.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2021 Aug; Vol. 132 (2), pp. e69-e77. Date of Electronic Publication: 2020 Aug 08.
DOI: 10.1016/j.oooo.2020.08.004
Abstrakt: Primordial odontogenic tumor (POT) is a recently described benign odontogenic tumor, with only 16 cases reported in the literature. We present 2 new cases of POT affecting the mandible. Case 1 is that of 12-year-old girl with an asymptomatic, slow-growing mass, causing facial asymmetry. Radiography showed a well-defined unilocular radiolucency surrounding an impacted second premolar. Case 2 is that of a 13-year-old girl with a mass involving the crown of the unerupted third molar and showing similar radiographic features. Microscopically, both lesions were composed of variably cellular fibromyxoid tissue surrounded by thin ameloblastic epithelium, with stellate reticulum-like areas, but no mineralized tissue, yielding the diagnosis of POT. Immunohistochemical analysis showed diffuse expression of CK14 in epithelial cells, whereas CK19 was expressed mainly in the basal layer. Syndecan-1 (CD138) was expressed in the stellate-like regions and in the subepithelial zone. Both patients were treated surgically, with no signs of recurrence seen after 15 and 60 months, respectively.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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