A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety.

Autor: MacIlvane N; From the, Clinical NeuroImaging Research Core, (NM, SJF, EEP, RM), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA., Fede SJ; From the, Clinical NeuroImaging Research Core, (NM, SJF, EEP, RM), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA., Pearson EE; From the, Clinical NeuroImaging Research Core, (NM, SJF, EEP, RM), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA., Diazgranados N; Office of Clinical Director (ND), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA., Momenan R; From the, Clinical NeuroImaging Research Core, (NM, SJF, EEP, RM), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Jazyk: angličtina
Zdroj: Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2020 Nov; Vol. 44 (11), pp. 2212-2224. Date of Electronic Publication: 2020 Oct 27.
DOI: 10.1111/acer.14465
Abstrakt: Background: Individuals with alcohol use disorder (AUD) can present with comorbid anxiety symptoms and often have deficits in emotional processing. Previous research suggests brain response is altered during facial affect recognition tasks, especially in limbic areas, due to either AUD or anxiety symptomology; however, the impact of both AUD and clinically significant anxiety symptoms during these tasks has not yet been examined.
Methods: In this study, we investigated neural activation differences during an emotional face-matching task. Participants (N = 232) underwent fMRI scanning, as part of a larger study. Three groups were investigated: individuals with diagnosed AUD and elevated anxiety traits (AUD + ANX, n = 90), individuals with diagnosed AUD but non-clinically significant levels of anxiety (AUD-ANX, n = 39), and healthy controls (HC, n = 103).
Results: Our results illustrate distinct neurophenotypes of AUD, where individuals with comorbid anxiety symptomology have blunted emotional face processing while those with singular AUD are hyperresponsive.
Conclusions: This suggests AUD with anxiety symptomology may have a unique neurobiological underpinning, and treatment and intervention should be tailored to individual constellations of symptoms.
(© Published 2020. This article is a U.S. Government work and is in the public domain in the USA.)
Databáze: MEDLINE
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