Mental health and health related quality of life in mitochondrial POLG disease.

Autor: Hikmat O; Department of Pediatrics and Adolescent Medicine, Haukeland University Hospital, 5021 Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Norway. Electronic address: omar.hikmat@uib.no., Vederhus BJ; Department of Pediatrics and Adolescent Medicine, Haukeland University Hospital, 5021 Bergen, Norway; Western Norway University of Applied Sciences, Bergen, Norway., Benestad MR; Department of Pediatrics and Adolescent Medicine, Haukeland University Hospital, 5021 Bergen, Norway; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Engeset IME; Department of Clinical Medicine (K1), University of Bergen, Norway., Klingenberg C; Department of Paediatric and Adolescent Medicine, University Hospital of North Norway, Tromso, Norway; Paediatric Research Group, Department of Clinical Medicine, UiT- The Arctic University of Norway, Tromso, Norway., Rasmussen M; Women and Children's Division, Department of Clinical Neurosciences for Children, Oslo University Hospital, Oslo, Norway and Unit for Congenital and Hereditary Neuromuscular Disorders, Department of Neurology, Oslo University Hospital, Oslo, Norway., Tallaksen CM; Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Brodtkorb E; Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway., Elgen IB; Department of Clinical Medicine (K1), University of Bergen, Norway; Department of Child and Adolescent Psychiatry, Haukeland University Hospital, Bergen, Norway., Bindoff LA; Department of Clinical Medicine (K1), University of Bergen, Norway; Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway.
Jazyk: angličtina
Zdroj: Mitochondrion [Mitochondrion] 2020 Nov; Vol. 55, pp. 95-99. Date of Electronic Publication: 2020 Sep 23.
DOI: 10.1016/j.mito.2020.09.005
Abstrakt: We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine subscales of SCL-90-R, particularly phobic anxiety, depression and somatization. Further, patients reported considerably lower scores in all RAND-36 domains. This study revealed a global decline in mental health and poor quality of life in patients with POLG disease and highlights the need for increased awareness and systematic assessment in order to improve their quality of life and mental health.
(Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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