Influence of altitude on cerebral and splanchnic oxygen saturation in critically ill children during air ambulance transport.

Autor: Hannegård Hamrin T; Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden., Eksborg S; Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Barnläkemedelsgruppen, Norrbacka S3:04, Karolinska University Hospital Solna, Stockholm, Sweden., Berner J; Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden., Fläring U; Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden., Radell PJ; Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care, Karolinska Institutet, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Sep 25; Vol. 15 (9), pp. e0239272. Date of Electronic Publication: 2020 Sep 25 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0239272
Abstrakt: Objective: The aim of the current study was to investigate how cerebral and splanchnic oxygen saturation (rSO2-C and rSO2-A) in critically ill children transported in air ambulance was affected by flight with cabin pressurization corresponding to ≥ 5000 feet. A second aim was to investigate any differences between cyanotic and non-cyanotic children in relation to cerebral and splanchnic oxygen saturation during flight ≥ 5000 feet. The variability of the cerebral and splanchnic Near Infrared Spectroscopy (NIRS) sensors was evaluated.
Design: NIRS was used to measure rSO2-C and rSO2-A during transport of critically ill children in air ambulance. rSO2 data was collected and stored by the NIRS monitor and extracted and analyzed off-line after the transport. Prior to evaluation of the NIRS signals all zero and floor-effect values were removed.
Setting: The Pediatric Intensive Care Unit (PICU) at Astrid Lindgren Children's Hospital, Karolinska University Hospital in Stockholm, Sweden.
Patients: In total, 44 critically ill children scheduled for inter-hospital transport by a specialized pediatric transport team were included in the study between January 2014 and January 2019 (convenience sampling).
Intervention: No interventions were conducted.
Measurements: All study patients were monitored with a cerebral NIRS-sensor placed over the forehead and an abdominal NIRS-sensor placed in the infra-umbilical area for cerebral and splanchnic regional oxygen saturation monitoring, rSO2-C and rSO2-A, respectively.
Main Results: Complete rSO2-C and rSO2-A data was obtained in 39 patients. Median age was 12 days. Cyanotic congenital heart malformations were present in 9 patients (23%). In 22 patients (56%) rSO2-C decreased at altitude ≥ 5000 feet and in 24 patients (61%) rSO2-A decreased at altitude ≥ 5000 feet compared to baseline (p<0.0001). In 25 patients (64%) the rSO2-C/rSO2-A ratio was greater at altitude ≥ 5000 feet than at baseline. A ratio ≥ 1 was seen in 77% of patients at altitude ≥ 5000 feet compared to in 67% of patients at baseline.
Conclusion: Both cerebral and splanchnic oxygen saturation decreased at altitude ≥ 5000 feet compared to baseline. In most patients, both cyanotic and non-cyanotic, cerebral oxygen saturation was preserved more than splanchnic oxygen saturation.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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