Case Report: Concomitant Diagnosis of Plasma Cell Leukemia in Patient With JAK2 Positive Myeloproliferative Neoplasm.

Autor:	Kurian CJ; Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, United States., Thomas C; Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, United States., Houtmann S; Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, United States., Klumpp T; Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, United States., Binder AF; Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2020 Aug 27; Vol. 10, pp. 1497. Date of Electronic Publication: 2020 Aug 27 (Print Publication: 2020).
DOI:	10.3389/fonc.2020.01497
Abstrakt:	Plasma cell dyscrasias and myeloproliferative neoplasms (MPN) are hematologic malignancies arising from two distinct hematopoietic cell lineages. They rarely occur concomitantly. Here, we report a case of a patient with a recent diagnosis of a JAK2 V617F positive MPN who presented with a new diagnosis of plasma cell leukemia. The patient had presented to the hospital with a leukocytosis predominantly comprised of plasma cells, followed by work-up involving peripheral blood flow cytometry, FISH analysis, and bone-marrow biopsy. FISH analysis was suggestive of a common progenitor cell for these distinct hematologic malignancies. To our knowledge, this case represents the second reported instance of a concomitant JAK2 positive MPN with primary plasma cell leukemia. (Copyright © 2020 Kurian, Thomas, Houtmann, Klumpp and Binder.)
Databáze:	MEDLINE
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