Impaired Geriatric 8 Score is Associated with Worse Survival after Radiotherapy in Older Patients with Cancer.

Autor: Middelburg JG; Erasmus Medical Center, Radiotherapy, Rotterdam, the Netherlands. Electronic address: j.g.middelburg@gmail.com., Middelburg RA; Sanquin Research, Center for Clinical Transfusion Research, Leiden, the Netherlands; Leiden University Medical Center, Department of Clinical Epidemiology, Leiden, the Netherlands., van Zwienen M; Erasmus Medical Center, Radiotherapy, Rotterdam, the Netherlands., Mast ME; Haaglanden Medical Center, Department of Radiotherapy, The Hague, the Netherlands., Bhawanie A; Medisch Spectrum Twente, Radiation Oncology, Enschede, the Netherlands., Jobsen JJ; Medisch Spectrum Twente, Radiation Oncology, Enschede, the Netherlands., Rozema T; Institute Verbeeten, Radiotherapy, Tilburg, the Netherlands., Maas H; Elisabeth-Tweesteden Hospital, Department of Geriatric Medicine, Tilburg, the Netherlands., Geijsen ED; Academic Medical Center, Radiotherapy, Amsterdam, the Netherlands., van der Leest AH; University Medical Center Groningen, Radiotherapy, Groningen, the Netherlands., van den Bongard DHJG; University Medical Centre Utrecht, Department of Radiotherapy, Utrecht, the Netherlands., van Loon J; Maastricht University Medical Center, GROW-School for Oncology and Developmental Biology, Department of Radiation Oncology (Maastro Clinic), Maastricht, the Netherlands., Budiharto T; Catharina Ziekenhuis, Department of Radiotherapy, Eindhoven, the Netherlands., Aarts MJ; Netherlands Comprehensive Cancer Organization IKNL, Netherlands Cancer Registry, Utrecht, the Netherlands., Terhaard CHJ; University Medical Centre Utrecht, Department of Radiotherapy, Utrecht, the Netherlands., Struikmans H; Haaglanden Medical Center, Department of Radiotherapy, The Hague, the Netherlands.
Jazyk: angličtina
Zdroj: Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2021 Apr; Vol. 33 (4), pp. e203-e210. Date of Electronic Publication: 2020 Sep 22.
DOI: 10.1016/j.clon.2020.09.002
Abstrakt: Aims: To investigate whether the Geriatric 8 (G8) score and the Timed Get Up and Go Test (TGUGT), together with clinical and demographic patient characteristics, are associated with survival and late toxicity after (chemo)radiation therapy, administered with curative intent in older patients with cancer.
Materials and Methods: Four hundred and two patients aged ≥65 years (median age 72 years, range 65-96 years), diagnosed with either breast, non-small cell lung, prostate, head and neck, rectal or oesophageal cancer, and referred for curative (chemo)radiation therapy, took part in a multicentre prospective cohort study in eight radiotherapy centres in the Netherlands. The G8 and TGUGT scores were assessed before starting treatment. Other potential predictors and late toxicity were also recorded. Survival status and date of death, if applicable, were ascertained at the Dutch national death registry.
Results: After 2.5 years, the overall survival was 83%. Survival was 87% for patients with high G8 scores and 55% for patients with low G8 scores (Log-rank P value < 0.0001). Survival was 77% for patients with good TGUGT results and 50% for patients with poor TGUGT results (Log-rank P value < 0.001). In multivariable analysis, in addition to age and type of primary tumour, the association of the G8 score with overall survival remained, with a hazard ratio of 2.1 (95% confidence interval 1.2-3.8) for low versus high scores.
Conclusions: G8 was associated with overall survival in older patients with cancer irradiated with curative intent. This association was independent of the predictive value of age and primary tumour.
(Copyright © 2020 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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