| Autor: |
Rezvova MA; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Yuzhalin AE; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Glushkova TV; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Makarevich MI; Research Institute for Physical Chemical Problems of the Belarusian State University, 220030 Minsk, Belarus.; Faculty of Chemistry, Belarusian State University, 220006 Minsk, Belarus., Nikishau PA; Research Institute for Physical Chemical Problems of the Belarusian State University, 220030 Minsk, Belarus.; Faculty of Chemistry, Belarusian State University, 220006 Minsk, Belarus., Kostjuk SV; Research Institute for Physical Chemical Problems of the Belarusian State University, 220030 Minsk, Belarus.; Faculty of Chemistry, Belarusian State University, 220006 Minsk, Belarus.; Institute of Regenerative Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Russia., Klyshnikov KY; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Matveeva VG; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Khanova MY; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia., Ovcharenko EA; Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia. |
| Abstrakt: |
In this study, we incorporated carbon nanotubes (CNTs) into poly(styrene- block -isobutylene- block -styrene) (SIBS) to investigate the physical characteristics of the resulting nanocomposite and its cytotoxicity to endothelial cells. CNTs were dispersed in chloroform using sonication following the addition of a SIBS solution at different ratios. The resultant nanocomposite films were analyzed by X-ray microtomography, optical and scanning electron microscopy; tensile strength was examined by uniaxial tension testing; hydrophobicity was evaluated using a sessile drop technique; for cytotoxicity analysis, human umbilical vein endothelial cells were cultured on SIBS-CNTs for 3 days. We observed an uneven distribution of CNTs in the polymer matrix with sporadic bundles of interwoven nanotubes. Increasing the CNT content from 0 wt% to 8 wt% led to an increase in the tensile strength of SIBS films from 4.69 to 16.48 MPa. The engineering normal strain significantly decreased in 1 wt% SIBS-CNT films in comparison with the unmodified samples, whereas a further increase in the CNT content did not significantly affect this parameter. The incorporation of CNT into the SIBS matrix resulted in increased hydrophilicity, whereas no cytotoxicity towards endothelial cells was noted. We suggest that SIBS-CNT may become a promising material for the manufacture of implantable devices, such as cardiovascular patches or cusps of the polymer heart valve. |
