A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks.

Autor: Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway; Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, China; Institute of Geriatric Immunology, School of Medicine, Jinan University, 510632, Guangzhou, China; Department of Geriatrics, The First Affiliated Hospital, Zhengzhou University, 450052, Zhengzhou, China. Electronic address: e.f.fang@medisin.uio.no., Xie C; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: xiechenglong1987@126.com., Schenkel JA; Durham University Department of Sports and Exercise Sciences, Durham, United Kingdom. Electronic address: j.a.schenkel@durham.ac.uk., Wu C; Global Health Research Center, Duke Kunshan University, 215316, Kunshan, China; Duke Global Health Institute, Duke University, Durham, 27710, North Carolina, USA. Electronic address: chenkai.wu@dukekunshan.edu.cn., Long Q; Global Health Research Center, Duke Kunshan University, 215316, Kunshan, China. Electronic address: qian.long@dukekunshan.edu.cn., Cui H; Department of Endodontics, Shanghai Stomatological Hospital, Fudan University, China; Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, China. Electronic address: hongh_cui@126.com., Aman Y; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway. Electronic address: yahyah.aman@medisin.uio.no., Frank J; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway. Electronic address: jfrank0990@gmail.com., Liao J; Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 510275, Guangzhou, China; Sun Yat-sen Global Health Institute, Institute of State Governance, Sun Yat-sen University, 510275, Guangzhou, China. Electronic address: liaojing5@mail.sysu.edu.cn., Zou H; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Kirby Institute, University of New South Wales, Sydney, Australia. Electronic address: zouhuachun@mail.sysu.edu.cn., Wang NY; Pinetree Care Group, 515 Tower A, Guomen Plaza, Chaoyang District, 100028, Beijing, China. Electronic address: ninie.wang@pinetreecare.com., Wu J; Department of Sociology and Work Science, University of Gothenburg, SE-405 30, Gothenburg, Sweden. Electronic address: jing.wu@gu.se., Liu X; School of Public Affairs, Zhejiang University, Hangzhou, 310058, Zhejiang, China. Electronic address: xtliu@zju.edu.cn., Li T; BGI-Shenzhen, Beishan Industrial Zone, 518083, Shenzhen, China; China National GeneBank, BGI-Shenzhen, 518120, Shenzhen, China. Electronic address: litao2@genomics.cn., Fang Y; Department of Public Health, Erasmus University Medical Centre, Rotterdam, the Netherlands. Electronic address: y.fang@erasmusmc.nl., Niu Z; Aladdin Healthcare Technologies Ltd., 25 City Rd, Shoreditch, London EC1Y 1AA, UK. Electronic address: zhangming@aladdinid.com., Yang G; Cardiovascular Research Centre, Royal Brompton Hospital, London, SW3 6NP, UK; and National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, United Kingdom. Electronic address: g.yang@imperial.ac.uk., Hong J; Mindrank AI, Hangzhou, Zhejiang Province, China. Electronic address: emailofwalter@gmail.com., Wang Q; Department of Geriatrics, The First Affiliated Hospital, Zhengzhou University, 450052, Zhengzhou, China. Electronic address: qiansmile320@163.com., Chen G; Institute of Geriatric Immunology, School of Medicine, Jinan University, 510632, Guangzhou, China. Electronic address: guobingchen@jnu.edu.cn., Li J; Department of Biochemistry and Molecular Biology, The Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences (CAMS)& Peking Union Medical University (PUMC), 5 Dondan Santiao Road, Beijing, 100730, China. Electronic address: jun_li@ibms.pumc.edu.cn., Chen HZ; Department of Biochemistry and Molecular Biology, The Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences (CAMS)& Peking Union Medical University (PUMC), 5 Dondan Santiao Road, Beijing, 100730, China. Electronic address: chenhouzao@ibms.cams.cn., Kang L; Department of Geriatrics, Peking Union Medical College Hospital, Beijing, 100730, China. Electronic address: kanglin_66@126.com., Su H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao. Electronic address: huanxingsu@um.edu.mo., Gilmour BC; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway. Electronic address: briancg@student.ibv.uio.no., Zhu X; Department of Toxicology, Zhejiang University School of Public Health, Hangzhou, 310058, Zhejiang, China; The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, Zhejiang, China. Electronic address: zhuxq@zju.edu.cn., Jiang H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address: jianghong73868@126.com., He N; School of Public Health, Fudan University, 200032, Shanghai, China; Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, 200032, Shanghai, China; Key Laboratory of Health Technology Assessment of Ministry of Health, Fudan University, 200032, Shanghai, China. Electronic address: nhe@fudan.edu.cn., Tao J; Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, 510080, Guangzhou, China. Electronic address: taojungz123@163.com., Leng SX; Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Electronic address: sleng1@jhmi.edu., Tong T; Research Center on Ageing, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Beijing, China. Electronic address: ttj@bjmu.edu.cn., Woo J; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: jeanwoowong@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2020 Dec; Vol. 64, pp. 101174. Date of Electronic Publication: 2020 Sep 21.
DOI: 10.1016/j.arr.2020.101174
Abstrakt: One of the key issues facing public healthcare is the global trend of an increasingly ageing society which continues to present policy makers and caregivers with formidable healthcare and socio-economic challenges. Ageing is the primary contributor to a broad spectrum of chronic disorders all associated with a lower quality of life in the elderly. In 2019, the Chinese population constituted 18 % of the world population, with 164.5 million Chinese citizens aged 65 and above (65+), and 26 million aged 80 or above (80+). China has become an ageing society, and as it continues to age it will continue to exacerbate the burden borne by current family and public healthcare systems. Major healthcare challenges involved with caring for the elderly in China include the management of chronic non-communicable diseases (CNCDs), physical frailty, neurodegenerative diseases, cardiovascular diseases, with emerging challenges such as providing sufficient dental care, combating the rising prevalence of sexually transmitted diseases among nursing home communities, providing support for increased incidences of immune diseases, and the growing necessity to provide palliative care for the elderly. At the governmental level, it is necessary to make long-term strategic plans to respond to the pressures of an ageing society, especially to establish a nationwide, affordable, annual health check system to facilitate early diagnosis and provide access to affordable treatments. China has begun work on several activities to address these issues including the recent completion of the of the Ten-year Health-Care Reform project, the implementation of the Healthy China 2030 Action Plan, and the opening of the National Clinical Research Center for Geriatric Disorders. There are also societal challenges, namely the shift from an extended family system in which the younger provide home care for their elderly family members, to the current trend in which young people are increasingly migrating towards major cities for work, increasing reliance on nursing homes to compensate, especially following the outcomes of the 'one child policy' and the 'empty-nest elderly' phenomenon. At the individual level, it is important to provide avenues for people to seek and improve their own knowledge of health and disease, to encourage them to seek medical check-ups to prevent/manage illness, and to find ways to promote modifiable health-related behaviors (social activity, exercise, healthy diets, reasonable diet supplements) to enable healthier, happier, longer, and more productive lives in the elderly. Finally, at the technological or treatment level, there is a focus on modern technologies to counteract the negative effects of ageing. Researchers are striving to produce drugs that can mimic the effects of 'exercising more, eating less', while other anti-ageing molecules from molecular gerontologists could help to improve 'healthspan' in the elderly. Machine learning, 'Big Data', and other novel technologies can also be used to monitor disease patterns at the population level and may be used to inform policy design in the future. Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades. This is the 2nd edition of the review paper (Fang EF et al., Ageing Re. Rev. 2015).
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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