Biochemical markers after the Norseman Extreme Triathlon.

Autor: Nyborg C; Faculty of medicine, Department of Clinical medicine, University of Oslo, Oslo, Norway.; Section of Vascular Investigations, Oslo University Hospital, Aker, Norway., Melau J; Faculty of medicine, Department of Clinical medicine, University of Oslo, Oslo, Norway.; Section of Vascular Investigations, Oslo University Hospital, Aker, Norway.; Prehospital Division, Vestfold Hospital Trust, Tønsberg, Norway., Bonnevie-Svendsen M; Section of Vascular Investigations, Oslo University Hospital, Aker, Norway., Mathiasen M; Department of Cardiology, Telemark Hospital Trust, Notodden, Norway., Melsom HS; Faculty of medicine, Department of Clinical medicine, University of Oslo, Oslo, Norway.; Section of Vascular Investigations, Oslo University Hospital, Aker, Norway., Storsve AB; Aker BioMarine Antarctic AS, Lysaker, Norway., Hisdal J; Faculty of medicine, Department of Clinical medicine, University of Oslo, Oslo, Norway.; Section of Vascular Investigations, Oslo University Hospital, Aker, Norway.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Sep 23; Vol. 15 (9), pp. e0239158. Date of Electronic Publication: 2020 Sep 23 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0239158
Abstrakt: Prolonged exercise is known to cause changes in common biomarkers. Occasionally, competition athletes need medical assistance and hospitalisation during prolonged exercise events. To aid clinicians treating patients and medical teams in such events we have studied common biomarkers after at The Norseman Xtreme Triathlon (Norseman), an Ironman distance triathlon with an accumulated climb of 5200 m, and an Olympic triathlon for comparison. Blood samples were collected before, immediately after, and the day following the Norseman Xtreme Triatlon (n = 98) and Oslo Olympic Triathlon (n = 15). Increased levels of clinical significance were seen at the finish line of the Norseman in white blood cells count (WBC) (14.2 [13.5-14.9] 109/L, p < 0.001), creatinine kinase (CK) (2450 [1620-3950] U/L, p < 0.001) and NT-proBNP (576 [331-856] ng/L, p < 0.001). The following day there were clinically significant changes in CRP (39 [27-56] mg/L, p < 0.001) and Aspartate Aminotransferase (AST) (142 [99-191] U/L, p < 0.001). In comparison, after the Olympic triathlon distance, there were statistically significant, but less clinically important, changes in WBC (7.8 [6.7-9.6] 109/L, p < 0.001), CK (303 [182-393] U/L, p < 0.001) and NT-proBNP (77 [49-88] ng/L, p < 0.01) immediately after the race, and in CRP (2 [1-3] mg/L, p < 0.001) and AST (31 [26-41] U/L, p < 0.01) the following day. Subclinical changes were also observed in Hemoglobin, Thrombocytes, K+, Ca2+, Mg2+, Creatinine, Alanine Aminotransferase and Thyroxine after the Norseman. In conclusion, there were significant changes in biomarkers used in a clinical setting after the Norseman. Of largest clinical importance were clinically significant increased WBC, CRP, AST, CK and NT-proBNP after the Norseman. This is important to be aware of when athletes engaging in prolonged exercise events receive medical assistance or are hospitalised.
Competing Interests: The funder provided support in the form of research materials and salaries for author ABS but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Databáze: MEDLINE
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