Gestational Trophoblastic Neoplasia
| Autor: | AlJulaih GH; Imam Abdulrahman Bin Faisal University in AlKhobar, Saudi Arabia, Muzio MR; ASL NA3 SUD |
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| Jazyk: | angličtina |
| Zdroj: | 2022 Jan. |
| Abstrakt: | The first description of gestational trophoblastic disease (GTD) was by Hippocrates around 400 BC. Marchand discovered the association of this disease with pregnancy in 1895. Healthy trophoblastic tissue penetrates the endometrium, which creates a rich uterine vasculature, leading to a close connection between the fetus and the mother, which is called the placenta. Invasion is characteristic of malignant tissue, and fortunately, the malignant behavior of the healthy trophoblast is well controlled. Nevertheless, in gestational trophoblastic disease, the regulatory mechanisms become dysfunctional, resulting in highly invasive, vascular, and metastatic tumors. GTD involves both benign and malignant entities that include hydatidiform mole (complete and partial), choriocarcinoma, invasive mole, epithelioid trophoblastic tumor (ETT), and placental site trophoblastic tumor (PSTT). The last four are known as gestational trophoblastic neoplasia (GTN); all can metastasize and can be fatal if not treated.[1] (Copyright © 2022, StatPearls Publishing LLC.) |
| Databáze: | MEDLINE |
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