Correlation between computed tomography adapted leaman score and computed tomography liver and spleen attenuation parameters for non-alcoholic fatty liver disease as well as respective inflammatory mediators.

Autor: Hideo-Kajita A; Interventional Cardiology Department, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC, 20010, USA.; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Garcia-Garcia HM; Interventional Cardiology Department, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC, 20010, USA. Hector.M.GarciaGarcia@medstar.net.; Georgetown University School of Medicine, Washington, DC, USA. Hector.M.GarciaGarcia@medstar.net., Wopperer SB; Interventional Cardiology Department, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC, 20010, USA., Freire AFD; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Ozaki Y; Interventional Cardiology Department, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC, 20010, USA., Cavalcante R; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Bittencourt MS; Center for Clinical and Epidemiological Research and Division of Internal Medicine, University Hospital, University of São Paulo, Sao Paulo, SP, Brazil., Dan K; Interventional Cardiology Department, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC, 20010, USA., Soud M; Interventional Cardiology Department, MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC, 20010, USA., Pinheiro TL; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Falcão BAA; Hospital Do Coração De Messejana, Fortaleza, CE, Brazil., Falcão JLA; Hospital Do Coração De Messejana, Fortaleza, CE, Brazil., Soares P; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Ribeiro E; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Rochitte CE; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil., Lemos PA; Instituto Do Coração (InCor), Universidade de São Paulo, Sao Paulo, SP, Brazil. pedro.lemos@einstein.br.; Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, Bloco A, 4º andar, Hemodinâmica, Sao Paulo, SP, 05652-900, Brazil. pedro.lemos@einstein.br.
Jazyk: angličtina
Zdroj: The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2020 Dec; Vol. 36 (12), pp. 2383-2391. Date of Electronic Publication: 2020 Sep 22.
DOI: 10.1007/s10554-020-02026-w
Abstrakt: Metabolic syndrome is a primary driver of vascular inflammation, plaque development, and atherosclerotic disease. The Computed Tomography-adapted Leaman Score (CT-LeSc) has been shown to be an independent predictor of cardiac events in coronary artery disease (CAD) patients but has never been studied for broader applicability. Non-alcoholic fatty liver disease (NAFLD) is associated with similar systemic inflammatory processes as CAD, and its presence as assessed by Computed Tomography Liver and Spleen Attenuation (CT-LSA) may impact on the extension of the CT-LeSc. The purpose of this study was to investigate the association between the CT-LeSc and NAFLD and to characterize and compare the inflammatory processes of each disease state. This was an exploratory study in which patients with known multivessel CAD who were scheduled to undergo percutaneous coronary intervention were included. CT-LeSc were graded on pre-existing criteria by two independent CoreLab analysts. CT-LSA parameters analyzed included the liver absolute attenuation value, liver and spleen attenuation difference and liver-to-spleen attenuation ratio and were scored by two independent CoreLab analysts as well. Inflammatory mediator analysis included routine laboratory draws for a variety of known signal molecules. The overall liver absolute attenuation value did not correlate significantly with the CT-LeSc, but the subgroup 50 to 65 HU showed moderately negative correlation (R =  - 0.629; p = 0.008). The overall liver and spleen attenuation difference did not correlate significantly with the CT-LeSc, but the subgroup 1 to 18 HU showed moderately positive correlation (R = 0.513; p = 0.017). The overall and subgroup liver-to-spleen attenuation ratio did not correlate with the CT-LeSc. The eosinophil and leukocyte ratio showed weakly negative correlation with the overall CT-LeSc (R =  - 0.4602; p = 0.008), and VCAM-1 showed moderately negative correlation with CT-LeSc < 16.0 (R =  - 0.5678; p = 0.022). Some CT-LSA parameters correlate with high risk CT-LeSc and may both provide complementary information for cardiovascular risk stratification. The significant metrics of liver absolute attenuation value and liver and spleen attenuation difference can be quickly completed in the clinical setting and may support a suspicion of CAD.
Databáze: MEDLINE
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