Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT).

Autor:	Grither WR; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA., Dickson BC; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada., Fuh KC; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA., Hagemann IS; Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Jazyk:	angličtina
Zdroj:	Gynecologic oncology reports [Gynecol Oncol Rep] 2020 Sep 06; Vol. 34, pp. 100636. Date of Electronic Publication: 2020 Sep 06 (Print Publication: 2020).
DOI:	10.1016/j.gore.2020.100636
Abstrakt:	Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1-NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses. (© 2020 The Author(s).)
Databáze:	MEDLINE
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