Chemicals Constituents Isolated from Cultivate Alpinia conchigera Griff. and Antimicrobial Activity.

Autor: Taib MNAM; School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia., Anuar N; School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia., Hanafiah KM; School of Biological Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia., Al-Shammary AAK; School of Biological Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia., Saaid M; School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia., Awang K; Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: Tropical life sciences research [Trop Life Sci Res] 2020 Apr; Vol. 31 (1), pp. 159-178. Date of Electronic Publication: 2020 Apr 07.
DOI: 10.21315/tlsr2020.31.1.10
Abstrakt: Alpinia conchigera Griff. is a plant species from the family Zingiberaceae. Coloquially known as wild ginger, Alpinia conchigera Griff. is used as food condiment and for traditional treatment of skin diseases. Isolation studies to identify bioactive compounds of rhizomes of Alpinia conchigera yielded seven compounds; 1' S -1'-acetoxychavicol acetate ( 1 ), trans - p -coumaryl diacetate ( 2 ), p -hydroxycinnamyl acetate ( 3 ), 1' S -1'-hydroxychavicol acetate ( 4 ) p -hydroxybenzaldehyde ( 5 ), stigmasterol ( 6 ) and β -sitosterol ( 7 ). Compounds 1 , 2 and 5 were evaluated for antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). Among the compounds tested, Compound 1 showed good antimicrobial activity against the strain of MRSA with minimum inhibition concentration (MIC) value of 0.5 mg/mL. Meanwhile, Compounds 2 and 5 exhibited moderate activity with MIC value between 1.0 and 2.0 mg/mL. These findings indicate antimicrobial potential of 1' S -1'-acetoxychavicol acetate ( 1 ), compound derived from rhizome of Alpinia conchigera Griff. against MRSA, which warrant further investigation.
(© Penerbit Universiti Sains Malaysia, 2020.)
Databáze: MEDLINE
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