Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Autor: Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Roshchupkin GV; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Adams HHH; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Knol MJ; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Zare H; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, USA.; Department of Cell Systems & Anatomy, The University of Texas Health Science Center, San Antonio, TX, USA., Ahmad S; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Armstrong NJ; Mathematics and Statistics, Murdoch University, Perth, Australia., Satizabal CL; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Bernard M; Hospital for Sick Children, Toronto, ON, Canada., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA., Gillespie NA; Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.; QIMR Berghofer Medical Research Institute, Herston, QLD, Australia., Luciano M; Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Mishra A; University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Xia R; Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Jian X; Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Mosley TH; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Saba Y; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Pirpamer L; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Seiler S; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA, USA.; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA., Becker JT; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA., Carmichael O; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA., Lopez OL; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., van der Lee SJ; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Himali JJ; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Maillard P; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA, USA.; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA., Beiser AS; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., DeCarli C; Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology, University of California-Davis, Davis, CA, USA.; Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USA., Karama S; McGill University, Montreal Neurological Institute, Montreal, QC, Canada., Lewis L; McGill University, Montreal Neurological Institute, Montreal, QC, Canada., Harris M; Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK., Bastin ME; Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK., Deary IJ; Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Veronica Witte A; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, Leipzig, Germany., Beyer F; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, Leipzig, Germany., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia., Schofield PR; Neuroscience Research Australia, Sydney, Australia.; School of Medical Sciences, University of New South Wales, Sydney, Australia., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Kwok JB; School of Medical Sciences, University of New South Wales, Sydney, Australia.; Brain and Mind Centre - The University of Sydney, Camperdown, NSW, Australia., Wright MJ; Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.; Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, Australia., Ames D; National Ageing Research Institute, Royal Melbourne Hospital, Parkvill, VIC, Australia.; Academic Unit for Psychiatry of Old Age, University of Melbourne, St George's Hospital, Kew, VIC, Australia., Trollor J; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Jiang J; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, Australia., Wen W; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia., Vernooij MW; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Hofman A; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Uitterlinden AG; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Niessen WJ; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands., Wittfeld K; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Bülow R; Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Pausova Z; Hospital for Sick Children, Toronto, ON, Canada.; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, Canada., Bruce Pike G; Departments of Radiology and Clinial Neurosciences, University of Calgary, Calgary, AB, Canada., Maingault S; Institut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux, Bordeaux, France., Crivello F; Institut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux, Bordeaux, France., Tzourio C; University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France.; Pole de santé publique, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Amouyel P; Centre Hospitalier Universitaire de Bordeaux, France; Inserm U1167, Lille, France.; Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France.; Department of Public Health, Lille University Hospital, Lille, France., Mazoyer B; Institut des Maladies Neurodégénratives UMR5293, CEA, CNRS, University of Bordeaux, Bordeaux, France., Neale MC; Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA., Franz CE; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Lyons MJ; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA., Panizzon MS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Andreassen OA; NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Dale AM; Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, CA, USA., Logue M; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Center for PTSD at Boston VA Healthcare System, Boston, MA, USA.; Department of Psychiatry and Department of Medicine-Biomedical Genetics Section, Boston University School of Medicine, Boston, MA, USA., Grasby KL; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Painter JN; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Colodro-Conde L; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Bralten J; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.; Neuroscience Biomarkers, Janssen Research and Development, LLC, San Diego, CA, USA., Lind PA; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Pizzagalli F; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Stein JL; Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia., Kremen WS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Wardlaw JM; Centre for Cognitive Epidemiology and Cognitive Ageing, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK., Villringer A; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany., van Duijn CM; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Grabe HJ; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Longstreth WT Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Fornage M; Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Paus T; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.; Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada., Debette S; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, Bordeaux, France.; CHU de Bordeaux, Department of Neurology, F-33000, Bordeaux, France., Ikram MA; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. reinhold.schmidt@medunigraz.at., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, USA. suseshad@bu.edu.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. suseshad@bu.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2020 Sep 22; Vol. 11 (1), pp. 4796. Date of Electronic Publication: 2020 Sep 22.
DOI: 10.1038/s41467-020-18367-y
Abstrakt: Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Databáze: MEDLINE