Insights into the evolution of IG genes in Amphibians and reptiles.

Autor: Olivieri DN; Centro de Intelixencia Artificial, Ourense, Spain; ESEI, Dept. Informatics, Universidade de Vigo. As Lagoas S/n, Ourense, Spain. Electronic address: dolivieri@gmail.com., Mirete-Bachiller S; Unidad de Inmunología Hospital Do Meixoeiro, Vigo, Spain., Gambón-Deza F; Unidad de Inmunología Hospital Do Meixoeiro, Vigo, Spain. Electronic address: fgambon@gmail.com.
Jazyk: angličtina
Zdroj: Developmental and comparative immunology [Dev Comp Immunol] 2021 Jan; Vol. 114, pp. 103868. Date of Electronic Publication: 2020 Sep 17.
DOI: 10.1016/j.dci.2020.103868
Abstrakt: Immunoglobulins are essential proteins of the immune system to neutralize pathogens. Gene encoding B cell receptors and antibodies (Ig genes) first appeared with the emergence of early vertebrates having a jaw, and are now present in all extant jawed vertebrates, or Gnathostomata. The genes have undergone evolutionary changes. In particular, genomic structural changes corresponding to genes of the adaptive immune system were coincident or in parallel with the adaptation of vertebrates from the sea to land. In cartilaginous fish exist IgM, IgD/W, and IgNAR and in bony fish IgM, IgT, IgD. Amphibians and reptiles witnessed significant modifications both in the structure and orientation of IG genes. In particular, for these amphibians and Amniota that adapted to land, IgM and IgD genes were retained, but other isotypes arose, including genes for IgA(X)1, IgA(X)2, and IgY. Recent progress in high throughput genome sequencing is helping to uncover the IG gene structure of all jawed vertebrates. In this work, we review the work and present knowledge of immunoglobulin genes in genomes of amphibians and reptiles.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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