CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.

Autor: Galusic D; Department of Hematology, University Hospital of Split, Soltanska 1, 21000, Split, Croatia., Lucijanic M; Hematology Department, University Hospital Dubrava, Av. Gojka Suska 6, 10000, Zagreb, Croatia., Livun A; Clinical Institute of Laboratory Diagnosis, Division of Molecular Diagnosis and Genetics, University Hospital Dubrava, Av. Gojka Suska 6, 10000, Zagreb, Croatia., Radman M; Department of Endocrinology, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.; School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia., Lucijanic J; Health care center Zagreb-West, Prilaz baruna Filipovica 11, 10000, Zagreb, Croatia., Drmic Hofman I; School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia.; Department of Pathology, University Hospital of Split, Spinciceva 1, 21000, Split, Croatia., Kusec R; Hematology Department, University Hospital Dubrava, Av. Gojka Suska 6, 10000, Zagreb, Croatia. rkusec@irb.hr.; Clinical Institute of Laboratory Diagnosis, Division of Molecular Diagnosis and Genetics, University Hospital Dubrava, Av. Gojka Suska 6, 10000, Zagreb, Croatia. rkusec@irb.hr.; School of Medicine, University of Zagreb, Salata 3, 10000, Zagreb, Croatia. rkusec@irb.hr.
Jazyk: angličtina
Zdroj: Wiener klinische Wochenschrift [Wien Klin Wochenschr] 2022 Jan; Vol. 134 (1-2), pp. 83-85. Date of Electronic Publication: 2020 Sep 18.
DOI: 10.1007/s00508-020-01738-2
Abstrakt: Background: Cell division cycle 25c (CDC25c) is a gene coding a phosphatase controlling entry into mitosis upon activation through Polo-like kinase 1 (PLK1) and serves as a key regulator of cell division. The CDC25c was reported to be dysregulated in some malignant diseases, but its role in myelofibrosis has not yet been elucidated.
Methods: We have retrospectively investigated CDC25c mRNA expression in bone marrow aspirates of 43 patients with myelofibrosis (28 primary [PMF] and 15 secondary myelofibrosis [SMF]) and 12 controls.
Results: CDC25c mRNA expression did not significantly differ between PMF, SMF and controls (median ∆CT 3.08 vs 2.86 vs 2.29 for PMF, SMF and controls, respectively; P = 0.162). Patients presenting with higher CDC25c mRNA expression were of older age (P = 0.037), had statistically significantly higher white-blood-cells (P = 0.017), larger liver size (P = 0.022), higher absolute neutrophil (P = 0.010), monocyte (P = 0.050), basophil (P = 0.012), and eosinophil counts (P = 0.013). Patients presenting with high CDC25c mRNA expression had statistically significantly inferior overall survival compared to low CDC25c expression group (HR = 2.99; P = 0.049). Median overall survival was not reached in patients with low and was 44 months in patients with high CDC25c expression.
Conclusion: Our data suggest that higher CDC25c expression is associated with more proliferative phenotype of myelofibrosis and is prognostic of worse survival. Future studies investigating these interesting associations are warranted.
(© 2020. Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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