Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum .

Autor: Ahmed MMA; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Cairo, Egypt.; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA., Albadry MA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA., Ragab EA; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Cairo, Egypt., El-Ghaly EM; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Cairo, Egypt., Ismail SK; Faculty of Pharmacy, Department of Pharmacognosy, Al-Azhar University, Cairo, Egypt., Ali Z; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA., Khan SI; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.; Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA., Chittiboyina AG; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA., Khan IA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.; Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2022 Apr; Vol. 36 (7), pp. 1842-1850. Date of Electronic Publication: 2020 Sep 18.
DOI: 10.1080/14786419.2020.1821015
Abstrakt: Four undescribed cembranoids, sarcoroseolides A-D ( 1-4 ) along with nine reported related cembranoids ( 5-13 ) were isolated from the soft coral Sarcophyton roseum . The chemical structures of sarcoroseolides A - D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher's method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.
Databáze: MEDLINE