Bacteria-Derived Nanoparticles: Multifunctional Containers for Diagnostic and Therapeutic Applications.

Autor: Liu L; Department of Pharmacy, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, P. R. China.; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China., Wu J; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China., Gao J; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China., Lu X; Department of Pharmacy, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2020 Nov; Vol. 9 (22), pp. e2000893. Date of Electronic Publication: 2020 Sep 18.
DOI: 10.1002/adhm.202000893
Abstrakt: In recent decades, investigations on bacteria-derived materials have progressed from being a proof of concept to a means for improving traditional biomaterials. Owing to their unique characteristics, such as gene manipulation, rapid proliferation, and specific targeting, bacteria-derived materials have provided remarkable flexibility in applied biomedical functionalization. In this review, bacteria-derived nanoparticles are focused on as a promising biomaterial, introducing several bacterial species with great potential and useful strategies for fabrication. Through well-designed choices, bacteria-derived nanoparticles can be exploited to obtain functional bacteria-mimicking materials for a variety of applications, including cargo delivery, imaging, therapy, and immune modulation. Finally, the prospects and challenges of bacteria-derived nanoparticles are discussed. Particularly, safety concerns regarding the use of bacteria and their immunogenicity remain major obstacles to the clinical application of bacteria-derived nanoparticles and these concerns are immediate priorities for the research community.
(© 2020 Wiley-VCH GmbH.)
Databáze: MEDLINE
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