What do patients prefer? A multinational, longitudinal, qualitative study on patient-preferred treatment outcomes in early rheumatoid arthritis.

Autor:	Van der Elst K; Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium., Mathijssen EGE; Department of Rheumatology, Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands., Landgren E; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden.; Department of Rheumatology, Skåne University Hospital, Lund, Sweden., Bremander A; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., De Groef A; Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.; Patient Research Partner, KU Leuven University Hospitals Leuven, Leuven, Belgium., Lindqvist E; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden.; Department of Rheumatology, Skåne University Hospital, Lund, Sweden., Nylander M; Spenshult Research and Development Centre, Halmstad, Sweden.; Patient Research Partner, Swedish Rheumatism Association, Stockholm, Sweden., Peters A; Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands.; Patient Research Partner, Sint Maartenskliniek, Nijmegen, Netherlands., Van den Hoogen F; Department of Rheumatology, Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands., van Eijk-Hustings Y; Department of Rheumatology, Maastricht University Medical Centre, Maastricht, Netherlands.; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, Netherlands., Verhoeven G; Department of Rheumatology, Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands.; Patient Research Partner, Sint Maartenskliniek, Nijmegen, Netherlands., Vriezekolk JE; Department of Rheumatology, Sint Maartenskliniek Nijmegen, Nijmegen, Netherlands., Westhovens R; Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium.; Department of Development and Regeneration, Skeletal Biology and Engineering Research Centre, KU Leuven, Leuven, Belgium., Larsson I; Spenshult Research and Development Centre, Halmstad, Sweden ingrid.larsson@hh.se.; School of Health and Welfare, Halmstad University, Halmstad, Sweden.
Jazyk:	angličtina
Zdroj:	RMD open [RMD Open] 2020 Sep; Vol. 6 (2).
DOI:	10.1136/rmdopen-2020-001339
Abstrakt:	Objectives: To explore treatment outcomes preferred by patients with early rheumatoid arthritis (RA) and how these change throughout the early disease stage across three European countries. Methods: A longitudinal, qualitative, multicentre study was conducted in Belgium, the Netherlands and Sweden. 80 patients with early RA were individually interviewed 3-9 months after treatment initiation and 51 of them participated again in either a focus group or an individual interview 12-21 months after treatment initiation. Data were first analysed by country, following the Qualitative Analysis Guide of Leuven (QUAGOL). Thereafter, a meta-synthesis, inspired by the principles of meta-ethnography and the QUAGOL, was performed, involving the local research teams. Results: The meta-synthesis revealed 11 subthemes from which four main themes were identified: disease control, physical performance, self-accomplishment and well-being. 'A normal life despite RA' was an overarching patient-preferred outcome across countries. Belgian, Dutch and Swedish patients showed many similarities in terms of which outcomes they preferred throughout the early stage of RA. Some outcome preferences (eg, relief of fatigue and no side effects) developed differently over time across countries. Conclusions: This study on patient-preferred outcomes in early RA revealed that patients essentially want to live a normal life despite RA. Our findings help to understand what really matters to patients and provide specific insights into the early stage of RA, which should be addressed by clinicians of different disciplines from the start of treatment onwards. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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