Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster .

Autor:	Thompson JB; Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819, USA., Su OO; Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819, USA., Yang N; Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819, USA., Bauer JH; Department of Chemistry, California State University, Sacramento, 6000 J Street, Sacramento, CA 95819, USA j.bauer@csus.edu.
Jazyk:	angličtina
Zdroj:	Biology open [Biol Open] 2020 Sep 16; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 16.
DOI:	10.1242/bio.054361
Abstrakt:	Sleep deprivation has been shown to negatively impact health outcomes, leading to decreased immune responses, memory loss, increased activity of stress and inflammatory pathways, weight gain, and even behavioral changes. These observations suggest that sleep deprivation substantially interferes with important physiological functions, including metabolic pathways of energy utilization. Many of those phenotypes are correlated with age, suggesting that disrupted sleep may interfere with the aging process. However, little is known about how sleep disruption affects aging and longevity. Here, we investigate this relationship using eight representative fruit fly lines from the Sleep Inbred Panel (SIP). The SIP consists of 39 inbred lines that display extreme short- and long-sleep patterns, and constitutes a crucial Drosophila community resource for investigating the mechanisms of sleep regulation. Our data show that flies with short-sleep periods have ∼16% longer life span, as well as reduced aging rate, compared to flies with long-sleep. In contrast, disrupting normal circadian rhythm reduces fly longevity. Short-sleep SIP flies moreover show slight metabolic differences to long-sleep lines, and to flies with disrupted circadian rhythm. These data suggest that the inbred SIP lines engage sleep mechanisms that are distinct from the circadian clock system. Competing Interests: Competing interestsThe authors declare no competing or financial interests. (© 2020. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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