| Autor: |
Bulygin KV; Department of Human Anatomy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia.; Department of Normal and Topographic Anatomy, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia., Beeraka NM; Department of Biochemistry, Center of Excellence in Regenerative Medicine and Molecular Biology (CEMR), JSS Academy of Higher Education and Research (JSS AHER), Mysuru 570015, Karnataka, India., Saitgareeva AR; Department of Neurosurgery and Medical Rehabilitation with Courses IAPE, Bashkir State Medical University, 450008 Ufa, Russia., Nikolenko VN; Department of Human Anatomy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia.; Department of Normal and Topographic Anatomy, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia., Gareev I; Department of Neurosurgery and Medical Rehabilitation with Courses IAPE, Bashkir State Medical University, 450008 Ufa, Russia., Beylerli O; Department of Neurosurgery and Medical Rehabilitation with Courses IAPE, Bashkir State Medical University, 450008 Ufa, Russia., Akhmadeeva LR; Department of Neurosurgery and Medical Rehabilitation with Courses IAPE, Bashkir State Medical University, 450008 Ufa, Russia., Mikhaleva LM; Research Institute of Human Morphology, 3Tsyurupy Street, 117418 Moscow, Russia., Torres Solis LF; The School of Medicine, Universidad Autónoma de Aguascalientes, 20130 Aguascalientes, Mexico., Solís Herrera A; Human Photosynthesis© Research Centre, 20000 Aguascalientes, Mexico., Avila-Rodriguez MF; Department of Clinic Sciences, Science Health Faculty, University of Tolima, 730006299 Ibagué, Colombia., Somasundaram SG; Department of Biological Sciences, Salem University, Salem, WV 26426, USA., Kirkland CE; Department of Biological Sciences, Salem University, Salem, WV 26426, USA., Aliev G; Department of Human Anatomy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia.; Research Institute of Human Morphology, 3Tsyurupy Street, 117418 Moscow, Russia.; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.; GALLY International Research Institute, 7733 Louis Pasteur Drive, #330, San Antonio, TX 78229, USA. |
| Abstrakt: |
Ischemic stroke is one of the leading causes of death worldwide. Clinical manifestations of stroke are long-lasting and causing economic burden on the patients and society. Current therapeutic modalities to treat ischemic stroke (IS) are unsatisfactory due to the intricate pathophysiology and poor functional recovery of brain cellular compartment. MicroRNAs (miRNA) are endogenously expressed small non-coding RNA molecules, which can act as translation inhibitors and play a pivotal role in the pathophysiology associated with IS. Moreover, miRNAs may be used as potential diagnostic and therapeutic tools in clinical practice; yet, the complete role of miRNAs is enigmatic during IS. In this review, we explored the role of miRNAs in the regulation of stroke risk factors viz., arterial hypertension, metabolic disorders, and atherosclerosis. Furthermore, the role of miRNAs were reviewed during IS pathogenesis accompanied by excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis, neurogenesis, and Alzheimer's disease. The functional role of miRNAs is a double-edged sword effect in cerebral ischemia as they could modulate pathological mechanisms associated with risk factors of IS. miRNAs pertaining to IS pathogenesis could be potential biomarkers for stroke; they could help researchers to identify a particular stroke type and enable medical professionals to evaluate the severity of brain injury. Thus, ascertaining the role of miRNAs may be useful in deciphering their diagnostic role consequently it is plausible to envisage a suitable therapeutic modality against IS. |
