| Autor: |
Omenn GS; University of Michigan, Ann Arbor, Michigan 48109, United States.; Institute for Systems Biology, Seattle, Washington 98109, United States., Lane L; CALIPHO Group, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Overall CM; University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Cristea IM; Princeton University, Princeton, New Jersey 08544, United States., Corrales FJ; Centro Nacional de Biotecnologia, 28049 Madrid, Spain., Lindskog C; Uppsala University, 752 36 Uppsala, Sweden., Paik YK; Yonsei Proteome Research Center, Seoul 03722, Korea., Van Eyk JE; Cedars Sinai, Los Angeles, California 90048, United States., Liu S; BGI Group, Shenzhen 518083, China., Pennington SR; University College Dublin, Dublin 4, Ireland., Snyder MP; Stanford University, Stanford, California 94305, United States., Baker MS; Macquarie University, Macquarie Park, NSW 2109, Australia., Bandeira N; University of California, San Diego, La Jolla, California 92093, United States., Aebersold R; ETH-Zurich and University of Zurich, 8092 Zurich, Switzerland., Moritz RL; Institute for Systems Biology, Seattle, Washington 98109, United States., Deutsch EW; Institute for Systems Biology, Seattle, Washington 98109, United States. |
| Abstrakt: |
According to the 2020 Metrics of the HUPO Human Proteome Project (HPP), expression has now been detected at the protein level for >90% of the 19 773 predicted proteins coded in the human genome. The HPP annually reports on progress made throughout the world toward credibly identifying and characterizing the complete human protein parts list and promoting proteomics as an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2020-01 classified 17 874 proteins as PE1, having strong protein-level evidence, up 180 from 17 694 one year earlier. These represent 90.4% of the 19 773 predicted coding genes (all PE1,2,3,4 proteins in neXtProt). Conversely, the number of neXtProt PE2,3,4 proteins, termed the "missing proteins" (MPs), was reduced by 230 from 2129 to 1899 since the neXtProt 2019-01 release. PeptideAtlas is the primary source of uniform reanalysis of raw mass spectrometry data for neXtProt, supplemented this year with extensive data from MassIVE. PeptideAtlas 2020-01 added 362 canonical proteins between 2019 and 2020 and MassIVE contributed 84 more, many of which converted PE1 entries based on non-MS evidence to the MS-based subgroup. The 19 Biology and Disease-driven B/D-HPP teams continue to pursue the identification of driver proteins that underlie disease states, the characterization of regulatory mechanisms controlling the functions of these proteins, their proteoforms, and their interactions, and the progression of transitions from correlation to coexpression to causal networks after system perturbations. And the Human Protein Atlas published Blood, Brain, and Metabolic Atlases. |
