[Pathogenetic relationship between insulin resistance, insulin secretion and impaired glucose tolerance in patients with obesity].

Autor: Abdurakhmanova AM, Kosovskiĭ MI, Rakhimov NR, Guliamov TD
Jazyk: ruština
Zdroj: Problemy endokrinologii [Probl Endokrinol (Mosk)] 1988 Mar-Apr; Vol. 34 (2), pp. 21-4.
Abstrakt: The distribution of obese patients without diabetes based on the results of the oral glucose tolerance test (OGTT) made it possible to define 2 groups of patients: with normal (the 1st group) and disturbed (the 2nd group) OGTT. A moderate increase in the levels of insulin and C-peptide after GTT and almost unchanged sensitivity to insulin were observed in the 1st group. A considerable increase in the levels of insulin and C-peptide after glucose intake and a considerable decrease in the sensitivity to insulin were observed in the 2nd group. In obese patients with diabetes mellitus the levels of insulin and C-peptide after the GTT were significantly lower than those in the 1st and 2nd groups. A conclusion has been made that whereas certain stages of pathogenesis of diabetes mellitus in obesity are associated with hyperinsulinemia and GTT disorder, obvious diabetes mellitus is characterized by a decrease in secretory potentialities of the insular apparatus in parallel with glucose intolerance.
Databáze: MEDLINE