Autor: |
Abdurakhmanova AM, Kosovskiĭ MI, Rakhimov NR, Guliamov TD |
Jazyk: |
ruština |
Zdroj: |
Problemy endokrinologii [Probl Endokrinol (Mosk)] 1988 Mar-Apr; Vol. 34 (2), pp. 21-4. |
Abstrakt: |
The distribution of obese patients without diabetes based on the results of the oral glucose tolerance test (OGTT) made it possible to define 2 groups of patients: with normal (the 1st group) and disturbed (the 2nd group) OGTT. A moderate increase in the levels of insulin and C-peptide after GTT and almost unchanged sensitivity to insulin were observed in the 1st group. A considerable increase in the levels of insulin and C-peptide after glucose intake and a considerable decrease in the sensitivity to insulin were observed in the 2nd group. In obese patients with diabetes mellitus the levels of insulin and C-peptide after the GTT were significantly lower than those in the 1st and 2nd groups. A conclusion has been made that whereas certain stages of pathogenesis of diabetes mellitus in obesity are associated with hyperinsulinemia and GTT disorder, obvious diabetes mellitus is characterized by a decrease in secretory potentialities of the insular apparatus in parallel with glucose intolerance. |
Databáze: |
MEDLINE |
Externí odkaz: |
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