Sympathetic nerves control bacterial clearance.

Autor: Lankadeva YR; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., May CN; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., McKinley MJ; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., Neeland MR; Murdoch Children's Research Institute, Parkville, VIC, Australia., Ma S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., Hocking DM; Department of Microbiology and Immunology, University of Melbourne At the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Robins-Browne R; Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Microbiology and Immunology, University of Melbourne At the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Bedoui S; Department of Microbiology and Immunology, University of Melbourne At the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Farmer DGS; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia., Bailey SR; Faculty of Veterinary Science, University of Melbourne, Parkville, VIC, Australia., Martelli D; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia.; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy., McAllen RM; Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. rmca@florey.edu.au.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Sep 14; Vol. 10 (1), pp. 15009. Date of Electronic Publication: 2020 Sep 14.
DOI: 10.1038/s41598-020-72008-4
Abstrakt: A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but its consequences for host responses to live infection are unknown. To test this, conscious instrumented sheep were infected intravenously with live E. coli bacteria and followed for 48 h. A month previously, animals had undergone either bilateral splanchnic nerve section or a sham operation. As established for rodents, sheep with cut splanchnic nerves mounted a stronger systemic inflammatory response: higher blood levels of tumor necrosis factor alpha and interleukin-6 but lower levels of the anti-inflammatory cytokine interleukin-10, compared with sham-operated animals. Sequential blood cultures revealed that most sham-operated sheep maintained high circulating levels of live E. coli throughout the 48-h study period, while all sheep without splanchnic nerves rapidly cleared their bacteraemia and recovered clinically. The sympathetic inflammatory reflex evidently has a profound influence on the clearance of systemic bacterial infection.
Databáze: MEDLINE
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