Some Biochemical Perturbations May Modify the Understanding of Trypanotolerance in the West African Dwarf Sheep Infected With Trypanosoma brucei brucei and Trypanosoma congolense .

Autor: Anyogu DC; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria., Shoyinka SV; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria., Ihedioha JI; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, Nigeria.
Jazyk: angličtina
Zdroj: Clinical pathology (Thousand Oaks, Ventura County, Calif.) [Clin Pathol] 2020 Aug 14; Vol. 13, pp. 2632010X20938389. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
DOI: 10.1177/2632010X20938389
Abstrakt: Trypanosomes are single-celled protozoa that cause severe diseases in both humans and livestock in sub-Saharan African countries. The disease in the West African Dwarf (WAD) sheep is often neglected due to the issue of trypanotolerance. The current study is aimed to evaluate some biochemical changes in this breed that may modify the understanding of trypanotolerance. Fifteen WAD sheep were assigned into 3 groups (A, B, and C). Baseline (day 0) values of the parameters assayed were obtained before groups A and B were infected with Trypanosoma brucei brucei and Trypanosoma congolense , respectively, by intraperitoneal inoculation with 10 6 trypanosomes per animal. Standard procedures using Quimica Clinica Applicada (Spain) and Randox (UK) test kits were used to evaluate serum levels of AST, ALT, ALP, total protein, albumin, total cholesterol, urea, and creatinine on days 0, 14, 28, 42, 56, and 70 post infection. The infections caused sustained pyrexia, hypoproteinaemia, hypocholesterolaemia, weight loss, hepatitis, and mortalities although parasitaemia was greatly controlled especially in the T congolense infected rams. The findings suggest that the WAD rams are not just passive reservoirs of trypanosomes for human and animal infections, but experience active host-parasite interactions with huge price for resilience, biochemically.
Competing Interests: Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2020.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje