Serum Neopterin Is Not Influenced by Age and Blood Group of Transfusion-Transmitted Infection Negative Blood Donors.

Autor:	Ashfaq A; Physiology, Liaquat National Medical College, Karachi, PAK., Ejaz A; Nephrology, Jinnah Postgraduate Medical Centre, Karachi, PAK., Ahmed FK; Physiology, Sir Syed College of Medical and Dental Sciences for Girls, Karachi, PAK., Un Nisa N; Physiology, Jinnah Sindh Medical University, Karachi, PAK., Langhani S; Pathology, Jinnah Sindh Medical University, Karachi, PAK., Riffat S; Physiology, Jinnah Sindh Medical University, Karachi, PAK., Ariff M; Internal Medicine, Dow University of Health Sciences, Karachi, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2020 Aug 10; Vol. 12 (8), pp. e9636. Date of Electronic Publication: 2020 Aug 10.
DOI:	10.7759/cureus.9636
Abstrakt:	Objectives To measure serum neopterin levels in blood donors of the local population and to study its relationship with age and blood group of transfusion-transmitted infection (TTI) negative blood donors. Methodology This cross-sectional study was carried out in the Department of Physiology at Liaquat National Hospital and Medical College (LNMC), Karachi, Pakistan, in collaboration with the Basic Medical Sciences Institute and Jinnah Post Graduate Medical Centre (JPMC). Data were collected from January 2018 to July 2018. A total of 174 blood donors participated in the study, who were selected by using a random sampling technique. They were screened through the standard procedures used for screening at the JPMC blood bank for TTIs as per the World Health Organization recommendations. Serum neopterin was estimated using enzyme-linked immunosorbent assay (ELISA) kits. Data analysis was performed using Statistical Package for Social Sciences (SPSS) version 23 (IBM Corp., Armonk, NY, USA). Chi-square and ANOVA (analysis of variance) were applied, and tests of significance were kept as P < 0.05. Results Neopterin level in the serum of TTI-positive blood donors was 15.1 ± 4.59 nmol/L, which was above the normal range and cutoff value of 10 nmol/L, whereas the neopterin level in the serum of TTI-negative blood donors was 6.1 ± 1.82 nmol/L (P = 0.001). In TTI-negative blood donors, the neopterin levels were within normal limits and were not influenced by age and blood groups (P > 0.05). Conclusions Serum neopterin levels did not report any significant difference in terms of age and blood group of TTI-negative blood donors and were seen to be within normal limits. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2020, Ashfaq et al.)
Databáze:	MEDLINE
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