Body Mass Index and Prognosis of COVID-19 Infection. A Systematic Review.

Autor:	Peres KC; Laboratory of Cancer Molecular Genetics, School of Medical Sciences, University of Campinas, Campinas, Brazil., Riera R; Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.; Centre of Health Technology Assessment, Hospital Sírio-Libanês, São Paulo, Brazil., Martimbianco ALC; Postgraduate Program in Health and Environment, Universidade Metropolitana de Santos, São Paulo, Brazil.; Centro Universitário São Camilo, São Paulo, Brazil., Ward LS; Laboratory of Cancer Molecular Genetics, School of Medical Sciences, University of Campinas, Campinas, Brazil., Cunha LL; Laboratory of Cancer Molecular Genetics, School of Medical Sciences, University of Campinas, Campinas, Brazil.; Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 Aug 14; Vol. 11, pp. 562. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
DOI:	10.3389/fendo.2020.00562
Abstrakt:	A better understanding of the SARS-CoV-2 virus behavior and possible risk factors implicated in poor outcome has become an urgent need. We performed a systematic review in order to investigate a possible association between body weight and prognosis among patients diagnosed with COVID-19. We searched in Cochrane Library, EMBASE, MEDLINE, WHO-Global Literature on Coronavirus Disease, OpenGrey, and Medrxiv. We used the ROBINS-I tool or Cross-Sectional/Prevalence Study Quality tool from AHRQ, to evaluate the methodological quality of included studies. Nine studies (two prospective cohorts, four retrospective cohorts and three cross-sectional) were included and assessed the relationship between obesity and COVID-19 prognosis. Risk of bias of the included studies ranged from moderate to critical. Clinical and methodological heterogeneity among them precluded meta-analyses. Most of the included studies showed some degree of association to: (a) higher BMI and worse clinical presentation and (b) obesity and need of hospitalization. The results were inconsistent about the impact of obesity on mortality. Based on limited methodological quality studies, obesity seems to predict poor clinical evolution in patients with COVID-19. Further studies with appropriate prospective design are needed to reduce the uncertainty on this evidence. (Copyright © 2020 Peres, Riera, Martimbianco, Ward and Cunha.)
Databáze:	MEDLINE
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