| Autor: |
Pasin F; Internal Medicine Unit,ASST Cremona. f.pasin@asst-cremona.it., Mascalchi Calveri M; ASST Cremona. matt.mascalchi@gmail.com., Calabrese A; ASST Cremona. alb.calb@gmail.com., Pizzarelli G; ASST Cremona. gin.pizza@gmail.com., Bongiovanni I; ASST Cremona. isab.bongio@gmail.com., Andreoli M; ASST Cremona. michi.andre@gmail.com., Cattaneo C; ASST Brescia. chiara.catt@gmail.com., Rignanese G; ASST Cremona. gio.rignanese@asst-cremona.it. |
| Jazyk: |
angličtina |
| Zdroj: |
Acta bio-medica : Atenei Parmensis [Acta Biomed] 2020 Jul 13; Vol. 91 (3), pp. ahead of print. Date of Electronic Publication: 2020 Jul 13. |
| DOI: |
10.23750/abm.v91i3.10141 |
| Abstrakt: |
Covid-19 infection was a possible causal factor in the exhaustion and decrease number of NK clonal cells, resulting in a evident improvement of signs, symptoms and clinical features related to NK lymphoma refractory to previous immuno-chemiotherapy. It has been shown that SARS-CoV2 binds to ACE2. Covid-19 may infect NK cells to suppress their functions, as NK cells express angiotensin converting enzyme 2 (ACE2). The excessive production of proinflammatory cytokines in Covid-19 infection may have played a crucial role in lymphodepletion. Although not published in Covid-19, other RNA viruses that cause acute pulmonary infections promote NK cell apoptosis. In NK/T-cell lymphoma plasma EBV-DNA is a sensitive surrogate biomarker of lymphoma load. In this case, we also notice a dramatic transient reduction in plasmatic EBV-DNA viral copies during Covid-19 pneumonia other than NK clonal cells reduction, and after the infection resolution we described a lymphoma relapse as well as EBV-DNA increase and the rising in NK clonal cells count. Although the mechanism leading to spontaneous remission remain uncharacterized, we hypothezised that a favorable adaptive immunity against concurrent viral infection could render an enhanced anti-tumor effect. We suppose COVID-19 infection have induced a transient remission in this patient affected with NK neoplasm. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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