Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines.

Autor: McKelvey BA; Department of Surgery, Johns Hopkins University, Baltimore, MD, USA.; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA., Zeiger MA; Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Umbricht CB; Department of Surgery, Johns Hopkins University, Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: Molecular oncology [Mol Oncol] 2020 Oct; Vol. 14 (10), pp. 2355-2357. Date of Electronic Publication: 2020 Sep 19.
DOI: 10.1002/1878-0261.12798
Abstrakt: Telomerase regulation, including TERT promoter methylation, has been of long-standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with active TERT expression in cancer cells. They further describe the interplay between activating TERT promoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization of TERT promoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on: https://doi.org/10.1002/1878-0261.12786.
(© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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