Orbitofrontal sulcogyral morphology in patients with cocaine use disorder.

Autor: Patti MA; Geisinger-Bucknell Autism & Developmental Medicine Institute, Geisinger, 120 Hamm Drive, Suite 2A, Lewisburg, PA 17837, United States. Electronic address: marisa_patti@brown.edu., Wochele S; Geisinger-Bucknell Autism & Developmental Medicine Institute, Geisinger, 120 Hamm Drive, Suite 2A, Lewisburg, PA 17837, United States., Hu Y; Department of Population Health Sciences, Geisinger, Danville, PA, United States., Regier PS; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States., Childress AR; Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States., Troiani V; Geisinger-Bucknell Autism & Developmental Medicine Institute, Geisinger, 120 Hamm Drive, Suite 2A, Lewisburg, PA 17837, United States; Department of Imaging Science and Innovation, Center for Health Research, Geisinger, Danville, Pennsylvania, United States; Neuroscience Institute, Geisinger, Danville, Pennsylvania, United States; Department of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, United States. Electronic address: vtroiani@geisinger.edu.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2020 Nov 30; Vol. 305, pp. 111174. Date of Electronic Publication: 2020 Sep 02.
DOI: 10.1016/j.pscychresns.2020.111174
Abstrakt: Orbitofrontal cortex (OFC) is thought to be involved in appropriate processing of rewarding stimuli, and abnormal OFC structure and function has been found in patients with substance use disorders. Atypical patterns of the H-sulcus in the OFC have been primarily identified with schizophrenia, but also with bipolar disorder, both of which are associated with comorbid substance use. Given the high rates of substance use within Axis I psychiatric disorders, it is reasonable to consider how frequencies of OFC patterns in populations with only substance use compare to controls. This information is crucial to disentangle whether atypical frequencies of H-sulcus sulcogyral patterns within psychopathology are associated with the psychiatric or substance use phenotype. Here, we present the first analysis of H-sulcus sulcogyral patterns in a population of adult black men with (n = 84) and without (n = 24) cocaine use disorder (CUD). We find that OFC sulcogyral patterns are not significantly different from the control group, indicating that OFC sulcogyral patterns are not disrupted in patients with CUD. As exploratory analyses, we describe OFC sulcogyral pattern subtypes in this cohort as well as an additional control group (n = 52), in order to add to the growing body of literature on OFC sulcogyral pattern characterization.
(Copyright © 2020. Published by Elsevier B.V.)
Databáze: MEDLINE
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