Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force.
| Autor: | Bezer JH; Department of Bioengineering, Imperial College London, London, United Kingdom., Koruk H; Mechanical Engineering Department, MEF University, Istanbul, Turkey., Rowlands CJ; Department of Bioengineering, Imperial College London, London, United Kingdom., Choi JJ; Department of Bioengineering, Imperial College London, London, United Kingdom. Electronic address: j.choi@imperial.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Ultrasound in medicine & biology [Ultrasound Med Biol] 2020 Dec; Vol. 46 (12), pp. 3327-3338. Date of Electronic Publication: 2020 Sep 09. |
| DOI: | 10.1016/j.ultrasmedbio.2020.08.012 |
| Abstrakt: | Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25-100 µm, Young's modulus: 2-8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6-1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading-unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects. (Copyright © 2020 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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