Biocompatibility and stability during storage of Foley urinary catheters coated chlorhexidine loaded nanoparticles by nanocoating: in vitro and in vivo evaluation.

Autor: Srisang S; Department of Engineering, King Mongkut's Institute of Technology Ladkrabung, Prince of Chumphon campus, Chumphon, Thailand., Boongird A; Department of Surgery, Neurosurgical Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Ungsurungsie M; Research and Development Division, S and J International Enterprises Public Company Limited, Bangkok, Thailand., Wanasawas P; Research and Development Division, S and J International Enterprises Public Company Limited, Bangkok, Thailand., Nasongkla N; Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom, Thailand.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2021 Apr; Vol. 109 (4), pp. 496-504. Date of Electronic Publication: 2020 Sep 11.
DOI: 10.1002/jbm.b.34718
Abstrakt: Foley urinary catheters were coated by chlorhexidine-loaded micelles and chlorhexidine-loaded nanospheres. In our prior study, the nanocoating of Foley urinary catheter was investigated for chlorhexidine-release study, degradation, antibacterial evaluation, and cytotoxicity assessment. These studies presented the 1 month antibacterial property of nanocoating deposited via the layers of micelles and nanospheres. In this study, we evaluated the biocompatibility of these catheters, including hemocompatibility, skin irritation, skin sensitization, and stability during the age of coated urinary catheter. Results demonstrated that coated urinary catheters presented slight hemolysis, whereas skin irritation on rabbit and skin sensitization on Dunkin Hartley guinea pig showed no signs of dermal toxicity, which indicated that inflammation, redness, and swelling did not occur. Moreover, the stability of coated urinary catheters during storage indicated no change in chlorhexidine peaks by high performance liquid chromatography. Information from these studies supports the biocompatibility of coated urinary catheters via nanocoating and their use as indwelling devices to prevent urinary tract infections.
(© 2020 Wiley Periodicals LLC.)
Databáze: MEDLINE
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